{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:46:23Z","timestamp":1760985983437,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17k09263","JP18k10119"],"award-info":[{"award-number":["JP17k09263","JP18k10119"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>We pathologically investigated three autopsy cases of cystic tumor of the atrioventricular node (CTAVN) with sudden death. Case 1 was a 36\u2010year\u2010old woman without any clinical history. Case 2 was a 76\u2010year\u2010old man with an implanted pacemaker for complete atrioventricular block. Case 3 was a 45\u2010year\u2010old man with a history of first\u2010degree AV block and sinus bradycardia. Microscopically, all three cases showed the bilayered structure of tumor glands and corpora amylacea in the glandular lumens. Immunohistochemically, the inner cells of the tumor glands were positive for cytokeratin CAM5.2, CEA, EMA, olfactomedin\u20104 and alpha\u2010methylacyl\u2010coenzyme A racemase; the outer cells were positive for p63 and cytokeratin high molecular weight. In Case 1, androgen receptor and estrogen receptor were negative; progesterone receptor was focally positive in both the inner and outer cells. In Case 2, androgen receptor showed intermediate positivity in the inner cells; estrogen receptor and progesterone receptor were positive in the outer cells. Positive expression of both prostate\u2010specific antigen and prostate\u2010specific acid phosphate were found in the inner cells of both male cases. Because CTAVN cells exhibit different degrees of the prostatic phenotype depending on the patient's sex, we believe that CTAVN may originate from urogenital sinus tissue in some cases.<\/jats:p>","DOI":"10.1111\/pin.13052","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T06:11:02Z","timestamp":1608012662000},"page":"141-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sex\u2010dependent expression of prostatic markers and hormone receptors in cystic tumor of the atrioventricular node: A histopathological study of three cases"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7305-8137","authenticated-orcid":false,"given":"Shojiro","family":"Ichimata","sequence":"first","affiliation":[{"name":"Department of Legal Medicine, Faculty of Medicine University of Toyama Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Faculty of Medicine University of Toyama Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhisa","family":"Yajima","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hachinohe City Hospital Aomori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosei","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hachinohe City Hospital Aomori Japan"},{"name":"Department of Pathology PCL Morioka Iwate Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Nomoto","sequence":"additional","affiliation":[{"name":"Department of Pathology Kouseiren Takaoka Hospital Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6921-1768","authenticated-orcid":false,"given":"Naoki","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Faculty of Medicine University of Toyama Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1309\/GWT2PY0T77PBBA1A"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1080\/20961790.2019.1595349"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1111\/j.1440-1827.1998.tb03862.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.5858\/2010-0268-LER.1","article-title":"Cystic tumor of the atrioventricular node: A rare cardiac pseudoneoplastic lesion","volume":"134","author":"Cameselle\u2010Teijeiro J","year":"2010","journal-title":"Arch Pathol Lab Med"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1002\/path.1711240207"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1016\/S0002-9440(10)64346-5"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.3748\/wjg.v24.i17.1881"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.1371\/journal.pone.0074386"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.1002\/1097-0045(20000801)44:3<181::AID-PROS1>3.0.CO;2-L"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1038\/s41598-017-15832-5"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1186\/1532-429X-11-13"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1093\/europace\/eut378"},{"key":"e_1_2_10_14_1","first-page":"265","volume-title":"Robbins and Cotran pathologic basis of disease","author":"Kumar V","year":"2014"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.1253\/circj.69.1293"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_1","DOI":"10.1111\/j.1432-0436.2008.00278.x"},{"volume-title":"Langman's medical embryology","year":"2018","author":"Sadler TW","key":"e_1_2_10_17_1"},{"key":"e_1_2_10_18_1","first-page":"1057","article-title":"Tumor of the atrioventricular nodal region. 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