{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:21:01Z","timestamp":1790050861177,"version":"4.0.1"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["MHLW Research Program on Rare and Intractable Diseases Grant Number JPMH20FC1040"],"award-info":[{"award-number":["MHLW Research Program on Rare and Intractable Diseases Grant Number JPMH20FC1040"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>The utility of gastric biopsy for diagnosing immunoglobulin (Ig)G4\u2010related gastrointestinal disease (IgG4\u2010GID) remains unclear. Bottom\u2010heavy plasmacytosis (BHP) is a distinct feature of IgG4\u2010GID. To clarify the feasibility of using gastric biopsies to diagnose BHP in IgG4\u2010GID, we analyzed the histological features and immunostaining of gastric biopsy specimens from 31 known IgG4\u2010related disease (IgG4\u2010RD) patients and we assessed the presence of BHP in 1696 consecutive routine gastric biopsies. Cases with both &gt;10 IgG4\u2010positive plasma cells per high\u2010power field and an IgG4\/IgG\u2010positive ratio &gt;40% were defined as IgG4\u2010high. Ten of the 31 IgG4\u2010RD patients were concluded to have IgG4\u2010GID, in which IgG4\u2010positive plasma cells were notably detected at the deeper part of the mucosa. Six cases displayed BHP whereas the remaining four cases showed transmural infiltration with concomitant <jats:italic>Helicobacter pylori<\/jats:italic>\u2010associated gastritis. In addition to BHP, we identified two unique histologic features for IgG4\u2010GID: plasmacytic aggregation in the muscularis mucosae and permeative plasmacytic infiltration between fundic glands in the non\u2010atrophic mucosa. Six of the routine cases (0.35%) displayed BHP, including a case with IgG4\u2010RD. IgG4\u2010GID can be suspected by the presence of gastric biopsy specimens with characteristic histological features. Such cases are recommended to undergo further examinations to determine whether IgG4\u2010RD is present.<\/jats:p>","DOI":"10.1111\/pin.13059","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T03:30:02Z","timestamp":1609385402000},"page":"124-134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Utility of gastric biopsy in diagnosing IgG4\u2010related gastrointestinal disease"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2391-9306","authenticated-orcid":false,"given":"Kaori","family":"Uchino","sequence":"first","affiliation":[{"name":"Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama University  Okayama Japan"},{"name":"Department of Anatomic Pathology Kurashiki Central Hospital  Okayama 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