{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:32Z","timestamp":1740126032108,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>Uterine osteosarcoma has been reported, but it is an extremely rare tumor with highly aggressive behavior and poor prognosis. The pathogenesis of uterine osteosarcoma is not fully understood. Herein, we report on a high\u2010grade uterine sarcoma with focal osteosarcomatous differentiation that developed from a long\u2010standing <jats:italic>MED12<\/jats:italic>\u2010mutated leiomyoma. A 47\u2010year\u2010old nulligravida woman, with known uterine leiomyoma presented with abdominal pain and distention. Imaging analyses revealed a tumor with a large cystic area in the uterine corpus and multiple metastases in intrapelvic and paraaortic lymph nodes, left ovary and left lung. With a clinical diagnosis of uterine sarcoma the patient underwent abdominal total hysterectomy, bilateral salpingo\u2010oophorectomy, partial omentectomy and removal of the left obturator lymph node. Despite postoperative chemotherapy and radiation therapy, the tumor progressed rapidly. She died 18 weeks after the surgery. Histopathologic examination identified a high\u2010grade pleomorphic sarcoma in which focal osteoid production was observed. This high\u2010grade sarcoma with focal osteosarcomatous differentiation was located within the uterine leiomyoma, and Sanger sequencing showed the identical <jats:italic>MED12<\/jats:italic> L36R mutation in both the osteosarcomatous and leiomyomatous components supporting the shared origin of these two components. We, therefore, concluded that the high\u2010grade sarcoma with osteosarcomatous differentiation arose from the transformation of the precedent leiomyoma.<\/jats:p>","DOI":"10.1111\/pin.13065","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T20:03:28Z","timestamp":1610741008000},"page":"199-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High\u2010grade uterine sarcoma with osteosarcomatous differentiation arising from a <i>MED12\u2010<\/i>mutated leiomyoma, a case report"],"prefix":"10.1111","volume":"71","author":[{"given":"Minh\u2010Khang","family":"Le","sequence":"first","affiliation":[{"name":"Department of Pathology University of Yamanashi Yamanashi 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