{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:55:21Z","timestamp":1747187721003,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>Lymphoepithelioma\u2010like carcinoma is a poorly differentiated carcinoma with prominent lymphoid infiltration occurring in various organs but is exceedingly rare in the colorectal region. This malignancy is frequently associated with Epstein\u2013Barr virus (EBV). Here we report a case of EBV\u2010associated lymphoepithelioma\u2010like carcinoma of the cecum in an 84\u2010year\u2010old male who presented with occult blood. <jats:italic>In situ<\/jats:italic> hybridization for EBV\u2010encoded small RNAs (EBER) in an endoscopic submucosal dissection specimen showed that the tumor consisted of EBER\u2010negative well\u2010differentiated tubular adenocarcinoma and EBER\u2010positive lymphoepithelioma\u2010like carcinoma. Real\u2010time PCR detected 7.16 copies of the EBV genome per cell in a sample microdissected from the latter component. Genotyping analysis demonstrated EBV genotype 1, and viral protein\/transcript expression in the tumor showed EBV latency I. Expression of Ephrin receptor A2, a recently reported receptor for EBV, was demonstrated in the tumor cells by immunohistochemistry. To our knowledge, this is the first report of lymphoepithelioma\u2010like carcinoma in the colorectal region showing a definite association with EBV infection.<\/jats:p>","DOI":"10.1111\/pin.13095","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T06:04:46Z","timestamp":1617257086000},"page":"420-426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A case of Epstein\u2013Barr virus\u2010associated lymphoepithelioma\u2010like carcinoma of the colon"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9403-1005","authenticated-orcid":false,"given":"Hiromi","family":"Kanno\u2010Okada","sequence":"first","affiliation":[{"name":"Department of Surgical Pathology Hokkaido University Hospital  Hokkaido 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