{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T21:40:43Z","timestamp":1773092443951,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myofibroblastoma is a rare benign mesenchymal tumor typically arising in the breast. We report a diagnostically challenging case of myofibroblastoma of the breast showing a rare palisaded morphology and an uncommon desmin\u2010 and CD34\u2010negative immunophenotype. A 73\u2010year\u2010old man underwent an excision for an 8 mm\u2010sized breast mass. Histology revealed that the tumor was composed of fascicles of bland spindle cells showing prominent nuclear palisading and Verocay\u2010like bodies. First, schwannoma, malignant peripheral nerve sheath tumor, and synovial sarcoma were suspected given the palisaded morphology. However, none of them was confirmed by immunohistochemical or molecular analyses. Next, a palisaded variant of myofibroblastoma was suspected by the morphology and coexpression of estrogen, progesterone and androgen receptors, BCL2 and CD10 in immunohistochemistry. However, the key diagnostic markers, desmin and CD34, were both negative. Finally, the diagnosis of myofibroblastoma was confirmed by detecting RB1 loss in immunohistochemistry and monoallelic 13q14 deletion (<jats:italic>RB1<\/jats:italic> and <jats:italic>FOXO1<\/jats:italic> loss) by fluorescence <jats:italic>in situ<\/jats:italic> hybridization assay. For the correct diagnosis of myofibroblastoma, it is important for pathologists to recognize the wide morphological spectrum, including a palisaded morphology, and the immunophenotypical variations, including desmin\u2010 and CD34\u2010negative immunophenotypes, and to employ a comprehensive diagnostic analysis through combined histological, immunohistochemical and molecular evaluations.<\/jats:p>","DOI":"10.1111\/pin.13106","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T20:54:56Z","timestamp":1621371296000},"page":"548-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Myofibroblastoma of the breast showing rare palisaded morphology and uncommon desmin\u2010 and CD34\u2010negative immunophenotype: A case report"],"prefix":"10.1111","volume":"71","author":[{"given":"Masashi","family":"Akiya","sequence":"first","affiliation":[{"name":"Division of Pathology Cancer Institute of Japanese Foundation for Cancer Research Tokyo Japan"},{"name":"Department of Pathology Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9250-4035","authenticated-orcid":false,"given":"Tomo","family":"Osako","sequence":"additional","affiliation":[{"name":"Division of Pathology Cancer Institute of Japanese Foundation for Cancer Research Tokyo Japan"},{"name":"Department of Pathology Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetomo","family":"Morizono","sequence":"additional","affiliation":[{"name":"Breast Oncology Center Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo Japan"},{"name":"Department of Cytology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Cytology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Ueno","sequence":"additional","affiliation":[{"name":"Breast Oncology Center Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Ohno","sequence":"additional","affiliation":[{"name":"Breast Oncology Center Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Pathology Cancer Institute of Japanese Foundation for Cancer Research Tokyo Japan"},{"name":"Department of Pathology Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo Japan"},{"name":"Pathology Project for Molecular Targets Cancer Institute of Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"71","volume-title":"Soft Tissue and Bone Tumours: World Health Organization Classification of Tumours","author":"Magro G","year":"2020"},{"key":"e_1_2_10_3_1","first-page":"204","volume-title":"Breast Tumours: World Health Organization Classification of Tumours","author":"Magro G","year":"2019"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.01.018"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896916665699"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12744"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5858\/132.11.1813"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000540"},{"key":"e_1_2_10_9_1","first-page":"211","volume-title":"Breast Tumours: World Health Organization Classification of Tumours","author":"Antonescu CR","year":"2019"},{"key":"e_1_2_10_10_1","unstructured":"NielsenGP ChiP. Malignant peripheral nerve sheath tumour. In: WHO Classification of Tumours Editorial Board Soft Tissue and Bone Tumours: World Health Organization Classification of Tumours.5th ed. Lyon: IARC Press 2020;254\u20137."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990615)85:12<2596::AID-CNCR16>3.0.CO;2-K"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.71"},{"key":"e_1_2_10_13_1","first-page":"290","volume-title":"Soft Tissue and Bone Tumours: World Health Organization Classification of Tumours","author":"Suurmeijer AJH","year":"2020"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10046"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pin.13106","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T16:12:50Z","timestamp":1693325570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.13106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,18]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/pin.13106"],"URL":"https:\/\/doi.org\/10.1111\/pin.13106","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,18]]},"assertion":[{"value":"2020-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}