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In 2015, the World Health Organization (WHO) histological classification defined the concepts of \u201cadenocarcinoma <jats:italic>in situ<\/jats:italic>\u201d (AIS) and \u201cminimally invasive adenocarcinoma\u201d (MIA), which are considered to be adenocarcinomas at a very early stage. Although AIS and MIA have a very favorable outcome, once they progress to early but invasive adenocarcinoma (eIA), they can sometimes have a fatal outcome. We previously compared the expression profiles of eIA and AIS, and identified stratifin (SFN; 14\u20103\u20103 sigma) as a protein showing significantly higher expression in eIA than in AIS. Expression of SFN is controlled epigenetically by DNA demethylation, and its overexpression is significantly correlated with poorer outcome. <jats:italic>In vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> analyses have shown that SFN facilitates early progression of adenocarcinoma by enhancing cell proliferation. This review summarizes genetic and epigenetic abnormalities that can occur in early\u2010stage lung adenocarcinoma and introduces recent findings regarding the biological significance of SFN overexpression during the course of lung adenocarcinoma progression. Therapeutic strategies for targeting SFN are also discussed.<\/jats:p>","DOI":"10.1111\/pin.13147","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T15:02:41Z","timestamp":1627570961000},"page":"655-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Significance of stratifin in early progression of lung adenocarcinoma and its potential therapeutic relevance"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6639-4135","authenticated-orcid":false,"given":"Aya","family":"Shiba\u2010Ishii","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology, Faculty of Medicine University of Tsukuba Tsukuba\u2010shi Ibaraki 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