{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:51:41Z","timestamp":1784631101704,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The diagnosis of histological transformation of follicular lymphoma can be challenging and ambiguous. We investigated the distribution of the Ki\u201067 labeling index of histological transformation of follicular lymphoma and determined its cutoff value to predict poor outcomes. The diagnostic criteria for histological transformation were a diffuse pattern of proliferation and a proportion of large lymphoma cells \u226520%. Of the 1121 patients with follicular lymphoma, 171 (15%) showed histological transformation to diffuse large B\u2010cell lymphoma. Of these, 76 patients, whose biopsies were obtained from the sites with the highest maximum standardized uptake values, according to the positron emission tomography findings, were included. The Ki\u201067 index ranged from 16.8% to 98.4% (median, 60.6%). In patients with histological transformation, the most significant differences were found in progression\u2010free survival (<jats:italic>p<\/jats:italic>\u2009=\u20090.087, 58% vs. 87% at 2 years) and overall survival (<jats:italic>p<\/jats:italic>\u2009=\u20090.024, 53% vs. 85% at 5 years) when a 70% cutoff was used. Additionally, overall survival was significantly shorter in patients with histological transformation with maximum standardized uptake values of \u226520 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and absence of a follicular lymphoma component (<jats:italic>p<\/jats:italic>\u2009=\u20090.004). A Ki\u201067 index of \u226570% was a significant adverse factor for overall survival in patients with histological transformation of follicular lymphoma and may predict poor outcomes.<\/jats:p>","DOI":"10.1111\/pin.13148","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T20:55:48Z","timestamp":1627937748000},"page":"674-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Diagnostic utility and prognostic significance of the Ki\u201067 labeling index in diffuse large B\u2010cell lymphoma transformed from follicular lymphoma: a study of 76 patients"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7251-7920","authenticated-orcid":false,"given":"Akiko Miyagi","family":"Maeshima","sequence":"first","affiliation":[{"name":"Department of Pathology National Cancer Center Hospital Tokyo 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