{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:48Z","timestamp":1740126048877,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This is the first case of follicular T\u2010cell lymphoma (FTCL) presenting as methotrexate\u2010associated lymphoproliferative disorders (MTX\u2010LPDs). A 69\u2010year\u2010old man treated rheumatoid arthritis with methotrexate presented with cervical swelling, hoarseness and fever. Imaging studies revealed multiple lymphadenopathy and lymphoma was suspected. Lymph node biopsy was performed to confirm the diagnosis. Pathologically, the lymph node was composed of atypical lymphocytes with a follicular growth pattern and area of necrosis. Immunohistochemical examination showed the atypical lymphocytes were positive for CD3, CD4, programmed cell death protein 1, and inducible T\u2010cell co\u2010stimulator. These findings are consistent with FTCL. During hospitalization, the patient's fever subsided and cervical lymphadenopathy improved, probably due to discontinuation of MTX. Here we presented the first case of FTCL presenting as MTX\u2010LPDs. The T\u2010cell phenotype MTX\u2010LPDs are relatively rare and accounts for only 3.4%\u20136.3% of all MTX\u2010LPD cases. Therefore, detailed clinicopathological features have not been clarified sufficiently. It is hoped that similar cases should be accumulated and studied to better understand the clinical and pathological features of this condition.<\/jats:p>","DOI":"10.1111\/pin.13155","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T19:50:39Z","timestamp":1630612239000},"page":"765-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The first case of methotrexate\u2010associated lymphoproliferative disorder presenting as follicular T\u2010cell lymphoma"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5251-5258","authenticated-orcid":false,"given":"Reiji","family":"Muto","sequence":"first","affiliation":[{"name":"Department of Pathology Fukuoka University School of Medicine  Fukuoka Japan"},{"name":"Department of Pathology Kurume University School of Medicine  Fukuoka Japan"},{"name":"Department of Pathology, National Hospital Organization 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