{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T14:29:49Z","timestamp":1747232989251,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We herein report three cases of mature teratomas with pineal gland differentiation, which is a less recognized phenomenon. Case 1 was a 6\u2010year\u2010old male with a neck mass, Case 2 was a 23\u2010year\u2010old female with a retroperitoneal mass, and Case 3 was a 45\u2010year\u2010old female with a retroperitoneal mass. Each case showed the typical macroscopic and histological findings of mature teratoma, such as solid and cystic lesions mainly lined with a mature squamous epithelium. All cases also showed glial differentiation. Small foci of lobulated cell nests were detected in the center of or adjacent to mature glial tissue. Cells had a clear to pale eosinophilic cytoplasm with small round nuclei. Immunohistochemically, cells were positive for synaptophysin, neurofilament protein with a perivascular \u201cclub\u2010shaped swelling\u201d pattern, and cone\u2010rod homeobox protein. To the best of our knowledge, this is the first report of pineal gland differentiation arising in mature teratoma, which may be easily overlooked or misdiagnosed as somatic\u2010type tumors, particularly neuroendocrine tumors. To avoid overtreatment, pathologists need to be aware that pineal gland differentiation may occur in mature teratomas.<\/jats:p>","DOI":"10.1111\/pin.13156","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T19:53:41Z","timestamp":1630612421000},"page":"771-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pineal gland differentiation in mature teratoma: An under\u2010recognized condition and potential pitfalls for overdiagnosis"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2806-2011","authenticated-orcid":false,"given":"Maki","family":"Kanzawa","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Kobe University Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kobe University Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Maruguchi","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Gon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepato\u2010Biliary\u2010Pancreatic Surgery Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuko","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kobe University Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2007-0252","authenticated-orcid":false,"given":"Masato","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kobe University Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0321-0770","authenticated-orcid":false,"given":"Tadashi","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7494-3496","authenticated-orcid":false,"given":"Takanori","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kobe University Hospital  Kobe Japan"},{"name":"Department of Diagnostic Pathology Hyogo Cancer Center  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoo","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kobe University Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"730","volume-title":"Robbins basic pathology","author":"Chang A","year":"2018"},{"key":"e_1_2_9_3_1","first-page":"138","volume-title":"WHO classification of tumours. 5th ed. 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