{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:37Z","timestamp":1787015917408,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Inverted ductal papilloma (IDP) is one of the least common benign papillary\/cystic neoplasms of the salivary duct system, being characterized histologically by florid hyperplasia of duct\u2010type epithelial cells into a cystic lumen near the orifice with occasional endophytic growth of the surface squamous epithelium along the terminus of the affected excretory duct. Given its rarity, the exact etiology of IDP remains to be defined. We herein present the first evidence of oncogenic\n                    <jats:italic>HRAS<\/jats:italic>\n                    mutation in a case of oral IDP. This finding, together with the frequent and specific\n                    <jats:italic>BRAF<\/jats:italic>\n                    mutations in sialadenoma papilliferum reported in the recent literature, supports an active role of the MAP\u2010kinase cascade in the pathogenesis of benign papillary neoplasms of terminal duct origin.\n                  <\/jats:p>","DOI":"10.1111\/pin.13166","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T17:05:40Z","timestamp":1632243940000},"page":"844-848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Activating\n                    <i>HRAS<\/i>\n                    mutation in a case of inverted ductal papilloma of the salivary gland"],"prefix":"10.1111","volume":"71","author":[{"given":"Fumio","family":"Ide","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Tsurumi University Dental Hospital Yokohama 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