{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:11:32Z","timestamp":1787731892590,"version":"build-2784847793"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["the Grant for surveys and research of amyloidosis"],"award-info":[{"award-number":["the Grant for surveys and research of amyloidosis"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["KAKEN\/ Grant No. 20K07389"],"award-info":[{"award-number":["KAKEN\/ Grant No. 20K07389"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K07389"],"award-info":[{"award-number":["20K07389"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An 85\u2010year\u2010old man with a history of aortic dissection suddenly fainted, underwent cardiac heart arrest, and died. An autopsy was performed, but the cause of death was not grossly identified. Congo red staining detected amyloid deposits in systemic organs, including the heart, lungs, liver, and kidneys. Immunohistochemical (IHC) analysis revealed immunoglobulin (Ig) \u03bb light chain (\u2010\u03bb) in systemic blood vessels and transthyretin (TTR) in the heart and lungs. Ig\u2010\u03bb was predominantly positive in the blood vessels of the lungs, while TTR was detected in the alveolar septum. In the heart, Ig\u2010\u03bb was positive in the endocardium and blood vessels, and TTR was positive in nodular deposits between cardiomyocytes. The concurrent deposition of Ig\u2010\u03bb and TTR in the heart was further substantiated by laser microdissection (LMD)\u2010liquid chromatography\u2010tandem mass spectrometry (LC\u2010MS\/MS) at each deposition site. Despite systemic deposition of Ig\u2010\u03bb, bone marrow biopsy findings were not diagnostic for multiple myeloma. In summary, we present an autopsy case of concurrent Ig\u2010\u03bb and TTR deposition as revealed by IHC and LC\u2010MS\/MS. When Congo red staining and IHC results are indeterminate due to the deposition of multiple amyloid proteins, LMD\u2010LC\u2010MS\/MS is useful for determining the precursor protein.<\/jats:p>","DOI":"10.1111\/pin.13179","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T05:11:22Z","timestamp":1634101882000},"page":"65-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Autopsy case with concurrent transthyretin and immunoglobulin amyloidosis"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-6176","authenticated-orcid":false,"given":"Yukako","family":"Shintani\u2010Domoto","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Nippon Medical School Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-9898","authenticated-orcid":false,"given":"Kousuke","family":"Ishino","sequence":"additional","affiliation":[{"name":"Department of Integrated Diagnostic Pathology Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7735-4382","authenticated-orcid":false,"given":"Hironobu","family":"Naiki","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology University of Fukui Fukui Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5959-3451","authenticated-orcid":false,"given":"Takashi","family":"Sakatani","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Nippon Medical School Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7053-038X","authenticated-orcid":false,"given":"Ryuji","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Nippon Medical School Hospital Tokyo Japan"},{"name":"Department of Integrated Diagnostic Pathology Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2020.1835263"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-019-0193-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2018.1449104"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-580720"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2020.01.001"},{"issue":"5","key":"e_1_2_7_7_1","first-page":"668","article-title":"Persistence of renal function in a patient diagnosed with concurrent amyloid amyloidosis and immunoglobulin light chain amyloidosis","volume":"58","author":"Watanabe R","year":"2016","journal-title":"Nihon Jinzo Gakkai Shi"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-20-0110"},{"issue":"6","key":"e_1_2_7_9_1","first-page":"1301","article-title":"Mechanisms of transthyretin amyloidogenesis. 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