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Commercial usage of asbestos is currently prohibited in Japan; however, the risk of asbestos\u2010induced malignant mesothelioma (MM) remains. According to epidemiological data, the onset of MM is estimated to occur after a latent period of 30\u201340 years from initial exposure to asbestos fibers; thus, the continuous increase in MM is a concern. To explore the molecular mechanisms of MM using animal models, iron saccharate with iron chelator\u2010induced sarcomatoid mesothelioma (SM) revealed hallmarks of homozygous deletion of <jats:italic>Cdkn2a\/2b<\/jats:italic> by aCGH and microRNA\u2010199\/214 by expression microarray. Oral treatment of iron chelation by deferasirox decreased the rate of high\u2010grade SM. Moreover, phlebotomy delayed MM development in crocidolite\u2010induced MM in rats. In <jats:italic>Divalent metal transporter 1<\/jats:italic> (<jats:italic>Dmt1<\/jats:italic>) transgenic mice, MM development was delayed because of low reactive oxygen species (ROS) production. These results indicate the importance of iron and ROS in mesothelial carcinogenesis. The aims of this review focus on the pathogenesis of elongated mineral particles (EMPs), including asbestos fibers and multiwalled carbon nanotubes (MWCNTs) that share similar rod\u2010like shapes in addition to the molecular mechanisms of MM development.<\/jats:p>","DOI":"10.1111\/pin.13196","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T15:34:09Z","timestamp":1640792049000},"page":"83-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Asbestos\u2010induced mesothelial injury and carcinogenesis: Involvement of iron and reactive oxygen species"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-9403","authenticated-orcid":false,"given":"Yasumasa","family":"Okazaki","sequence":"first","affiliation":[{"name":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Showa\u2010Ku Nagoya 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