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Blood examination showed elevated creatinine level, hypocomplementemia, and elevated anti\u2010streptolysin O level. Renal biopsy revealed endocapillary proliferative glomerulonephritis with tubulointerstitial nephritis (TIN). Immunofluorescence revealed C3\u2010dominant glomerular staining, while electron microscopy showed hump\u2010shaped subepithelial deposits. The patient was therefore diagnosed with poststreptococcal glomerulonephritis. The unique histological feature was C3 deposition in the tubular basement membrane (TBM), in which we detected streptococcal pyrogenic exotoxin B (SpeB), a nephritogenic antigen produced by streptococci. No nephritis\u2010associated plasmin receptor or plasmin activity was evident in the TBM. These nephritogenic antigens and upregulation of plasmin activity were observed in glomeruli. This case suggests that TIN after poststreptococcal infection might be partially attributable to SpeB toxicity.<\/jats:p>","DOI":"10.1111\/pin.13203","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T12:08:48Z","timestamp":1644581328000},"page":"200-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A case of acute poststreptococcal glomerulonephritis complicated by interstitial nephritis related to streptococcal pyrogenic exotoxin B"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6111-8027","authenticated-orcid":false,"given":"Nobuhiro","family":"Kanazawa","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine Showa University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Iyoda","sequence":"additional","affiliation":[{"name":"Division 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