{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:52Z","timestamp":1787015992434,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008886","name":"Princess Takamatsu Cancer Research Fund","doi-asserted-by":"publisher","award":["19\u2010251"],"award-info":[{"award-number":["19\u2010251"]}],"id":[{"id":"10.13039\/501100008886","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JPMJCR19H4"],"award-info":[{"award-number":["JPMJCR19H4"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19H05462 and JP20H05502"],"award-info":[{"award-number":["JP19H05462 and JP20H05502"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Malignant mesothelioma (MM) is still increasing worldwide. The pathogenesis depends on asbestos\u2010induced iron accumulation, which eventually leads to ferroptosis\u2010resistance of mesothelial cells via somatic mutations. Poly (\n                    <jats:italic>rC)<\/jats:italic>\n                    \u2010binding proteins 1 and 2 (PCBP1\/2) are recently recognized cytosolic Fe(II) chaperones. Here we studied the role of PCBP1\/2 in rat\/human mesothelial and MM cells as well as rat\/human MM specimens. Normal peritoneal mesothelial cells in rats exhibited PCBP1 but not PCBP2 immunopositivity whereas primary\/immortalized mesothelial cells showed PCBP1\/2 immunopositivity. Rat MM specimens induced by intraperitoneal injection of chrysotile, including in situ lesion, revealed PCBP1\/2 immunopositivity (90% for both) in the nucleus and cytoplasm with a tendency of higher expression in epithelioid subtype. Knockdown of\n                    <jats:italic>PCBP2<\/jats:italic>\n                    but not\n                    <jats:italic>PCBP1<\/jats:italic>\n                    significantly decreased both TfR1 and FTH expression in MM cells with inhibition of proliferation, indicating stagnation of intracellular iron transport. Erastin, a cysteine\u2010deprivation type ferroptosis inducer, decreased the expression of both PCBP1\/2 in MM cells. Furthermore,\n                    <jats:italic>PCBP2<\/jats:italic>\n                    knockdown significantly increased the sensitivity of MM cells to erastin\u2010induced ferroptosis with increased catalytic Fe(II). In conclusion, PCBP2 works for ferroptosis\u2010resistance not only during mesothelial carcinogenesis but also in MM, which warrants further investigation as a novel therapeutic target.\n                  <\/jats:p>","DOI":"10.1111\/pin.13209","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T08:41:19Z","timestamp":1643359279000},"page":"242-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["PCBP2 knockdown promotes ferroptosis in malignant mesothelioma"],"prefix":"10.1111","volume":"72","author":[{"given":"Lin","family":"Yue","sequence":"first","affiliation":[{"name":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaguang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2428-3848","authenticated-orcid":false,"given":"Yoshitaka","family":"Sekido","sequence":"additional","affiliation":[{"name":"Division of Cancer Biology Aichi Cancer Center Research Institute, 1\u20101 Kanokoden, Chikusa\u2010ku Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5757-1109","authenticated-orcid":false,"given":"Shinya","family":"Toyokuni","sequence":"additional","affiliation":[{"name":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan"},{"name":"Center for Low\u2010temperature Plasma Sciences Nagoya University, Furo\u2010cho, Chikusa\u2010ku Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"IARC WHO. Asbestos (chrysotile amosite crocidolite tremolite actinolite and anthophyllite). IARC monographs on the evaluation of carcinogenic risks to humans. A review of human carcinogens; Part C: Arsenic metals fibres and dusts. Vol. 100C. Lyon France: IARC;2012. p.219\u2013309."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.10.401"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0226-2020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15051000"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101616"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102174"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.02087.x"},{"key":"e_1_2_10_9_1","first-page":"1","article-title":"Mechanisms of asbestos\u2010induced carcinogenesis","volume":"71","author":"Toyokuni S","year":"2009","journal-title":"Nagoya J Med Sci"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2010.06.015"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2012.02326.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26158-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.07.020"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.09.006"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.01.014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.07.011"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113320"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.021"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14496"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13148"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.10.411"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2020.129685"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021010995"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.8.6243-6246.1997"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4075"},{"key":"e_1_2_10_26_1","first-page":"365","article-title":"Quantitative immunohistochemical determination of 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate\u2010induced renal carcinogenesis model","volume":"76","author":"Toyokuni S","year":"1997","journal-title":"Lab Invest"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2006.00184.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700280"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2014.898844"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.12408"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111719"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-20-0390"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2009.140"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0162-0134(92)84069-Y"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(95)02184-1"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/14.2.223"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1373"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043403"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15175"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110013108"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.05.011"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.09.022"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26873"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1157643"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.776021"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20140225"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.721936"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355838202024627"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1806912115"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.011870"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)01368-B"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pin.13209","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111\/pin.13209","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T17:01:32Z","timestamp":1692982892000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.13209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,28]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/pin.13209"],"URL":"https:\/\/doi.org\/10.1111\/pin.13209","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,28]]},"assertion":[{"value":"2021-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}