{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:36:22Z","timestamp":1791336982635,"version":"4.3.1"},"reference-count":60,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Neuroendocrine tumors (NET) with high proliferative activity (Ki\u201067 index &gt;20% and\/or mitotic counts &gt;2\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    ) are defined as NET G3 in the 2019 World Health Organization (WHO) classification of digestive system neuroendocrine neoplasms (NENs). NETs G3 occur mostly in the pancreas, colon, rectum, and stomach and only rarely in the small intestine and the appendix. In the bronchopulmonary system, similar tumors have also been recognized and were mostly classified as atypical carcinoid (AC) or large cell neuroendocrine carcinoma. Bronchopulmonary NENs that were classified as NETs G3 are characterized by histological and immunohistochemical similarities with carcinoids\/NETs, and a clinical course that is more aggressive than with ACs and similar to that of neuroendocrine carcinomas. The morphomolecular and clinical features of bronchopulmonary neoplasms with a high proliferative activity were reviewed and a future classification system that is applicable for both digestive and bronchopulmonary NETs is proposed.\n                  <\/jats:p>","DOI":"10.1111\/pin.13266","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T06:52:05Z","timestamp":1660891925000},"page":"488-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Neuroendocrine tumor G3 of bronchopulmonary origin and its classification"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1130-1744","authenticated-orcid":false,"given":"Atsuko","family":"Kasajima","sequence":"first","affiliation":[{"name":"Department of Pathology Technical University Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Kl\u00f6ppel","sequence":"additional","affiliation":[{"name":"Department of Pathology Technical University Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-20-0122"},{"key":"e_1_2_9_3_1","first-page":"16","volume-title":"WHO classification of tumours digestive system tumours","author":"Klimstra D","year":"2019"},{"key":"e_1_2_9_4_1","first-page":"133","volume-title":"WHO classification of tumours thoracic tumours","author":"Lantuejoul S","year":"2021"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0110-y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02955986"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-007-0021-9"},{"key":"e_1_2_9_8_1","first-page":"394","article-title":"Diabetes mellitus nach Pancreas extirpation","volume":"10","author":"Von Mering I","year":"1889","journal-title":"Zentral Klin Medzin"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1902.sp000920"},{"key":"e_1_2_9_10_1","first-page":"141","article-title":"Pancreatic extracts in the treatment of diabetes mellitus","volume":"12","author":"Banting FG","year":"1922","journal-title":"Can Med Assoc J"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)06206-2"},{"key":"e_1_2_9_12_1","first-page":"385","article-title":"Simple adenoma of the pancreas arising from an island of Langerhans","volume":"8","author":"Nicholls AG","year":"1902","journal-title":"J Med Res"},{"key":"e_1_2_9_13_1","first-page":"335","article-title":"Adenomas of the islands of Langerhans","volume":"2","author":"Warren S","year":"1926","journal-title":"Am J Pathol"},{"key":"e_1_2_9_14_1","first-page":"280","article-title":"Ueber den prim\u00e4ren Krebs des Ileum nebst Bemerkungen \u00fcber das gleichzeitige Vorkommen von Krebs und Tuberculose","volume":"111","author":"Lubarsch O","year":"1888","journal-title":"Archiv f\u00fcr pathologische Anatomie und Physiologie und f\u00fcr klinische Medicin"},{"key":"e_1_2_9_15_1","first-page":"424","article-title":"Karzinoide tumoren des d\u00fcnndarms","volume":"1","author":"Oberndorfer S","year":"1907","journal-title":"Frankf Z Pathol"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.09.018"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)64173-9"},{"key":"e_1_2_9_18_1","unstructured":"GossetA MassonP.Les tumeurs endocrines de l'appendice.Press med.1914;237\u201040"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1929.02710090014006"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-193506000-00001"},{"key":"e_1_2_9_21_1","first-page":"4","article-title":"[Metastatic carcinoid of the small intestine with severe valvular defects especially in the right part of the heart and with pulmonary stenosis; a peculiar symptom complex]","volume":"83","author":"Isler P","year":"1953","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_9_22_1","volume-title":"Die Geschw\u00fclste des Darms","author":"Oberndorfer S","year":"1929"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-191703000-00002"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01888109"},{"key":"e_1_2_9_25_1","first-page":"482","article-title":"Metastasizing bronchial adenomas","volume":"96","author":"McBurney RP","year":"1953","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(199005\/06)14:3<539::AID-CNCR2820140314>3.0.CO;2-P"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)39836-8"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)90951-6"},{"key":"e_1_2_9_29_1","volume-title":"Histological typing of endocrine tumours","author":"Williams ED","year":"1980"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00199342"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-59655-1"},{"key":"e_1_2_9_32_1","volume-title":"WHO classification of tumours thoracic tumours","author":"Travis WD","year":"2021"},{"key":"e_1_2_9_33_1","volume-title":"WHO classification of tumours. Tumors of the lung, pleura, thymus and heart","author":"Travis WD","year":"2004"},{"key":"e_1_2_9_34_1","volume-title":"WHO classification of tumours of the lung, pleura, thymus and heart","author":"Travis WD","year":"2015"},{"key":"e_1_2_9_35_1","volume-title":"WHO classification of tumours of the digestive system","author":"Bosman F","year":"2010"},{"key":"e_1_2_9_36_1","volume-title":"WHO classification of tumours of endocrine organs","author":"Lloyd RV","year":"2017"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2011.00020"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-13-0246"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-016-1568-z"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-017-2177-0"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0076-9"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2018.1441543"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495806"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-031531"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0248-2"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502776"},{"key":"e_1_2_9_47_1","volume-title":"WHO classification of tumours endocrine and neuroendocrine tumours","author":"Rindi G","year":"2022"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880459"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494355"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-021-03202-6"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506292"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-019-0886-1"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2020.10.015"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000767"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-13-0027"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2946"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0538-8"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4853"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2782"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.05.003"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11276-9"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pin.13266","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T01:25:34Z","timestamp":1692667534000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.13266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,19]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/pin.13266"],"URL":"https:\/\/doi.org\/10.1111\/pin.13266","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,19]]},"assertion":[{"value":"2022-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}