{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:39:48Z","timestamp":1771472388019,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 61\u2010year\u2010old woman without significant medical history developed fever 3 days after severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) vaccination and went into shock the next day. She was negative for SARS\u2010CoV\u20102 mRNA in real\u2010time polymerase chain reaction (PCR). Finally, she died 10 days after vaccination. At autopsy, the heart showed moderate dilatation of both ventricles, and the myocardium showed an uneven color change and decreased elasticity. Histologically, severe myocarditis with extensive myocytolysis was observed. The myocarditis showed severe inflammatory cell infiltration with T\u2010lymphocyte and macrophage predominance, and in addition to the inflammatory cells described above, vast nuclear dust accompanying neutrophilic infiltration was observed. In the bone marrow and lymph nodes, hemophagocytosis was observed. In postmortem examination, nucleic acids of any cardiotropic viruses including SARS\u2010CoV\u20102 were not detected using multivirus real\u2010time PCR system. We discussed the relationship between the possible immune reaction after vaccination and the myocarditis observed in this case from immunopathological viewpoints. This mRNA vaccine is the first applied nucleic acid vaccine for humans, and its mechanism of efficacy and immune acquisition remain unclear. We hope the accumulation of more detailed analyses of the similar cases to reveal the mechanism of this kind of adverse reaction.<\/jats:p>","DOI":"10.1111\/pin.13267","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T12:40:05Z","timestamp":1661863205000},"page":"519-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["An autopsy case of fulminant myocarditis after severe acute respiratory syndrome coronavirus 2 vaccine inoculation"],"prefix":"10.1111","volume":"72","author":[{"given":"Hidetoshi","family":"Satomi","sequence":"first","affiliation":[{"name":"Department of Pathology Nagano Red Cross Hospital Nagano Japan"},{"name":"Department of Pathology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harutaka","family":"Katano","sequence":"additional","affiliation":[{"name":"Department of Pathology National Institute of Infectious Diseases Shinjuku Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3200-9304","authenticated-orcid":false,"given":"Hiroyuki","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Pathology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2757-6117","authenticated-orcid":false,"given":"Mikiko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukari","family":"Ohkuma","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagano Red Cross Hospital Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Hashidume","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagano Red Cross Hospital Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagano Red Cross Hospital Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichi","family":"Tsukada","sequence":"additional","affiliation":[{"name":"Department of Cardiology Joetsu General Hospital Joetsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5315-085X","authenticated-orcid":false,"given":"Ichiro","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pathology Nagano Red Cross Hospital Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization(homepage on the internet). Gen\u00e8ve; World Health Organization. Coronavirus disease 2019 (\u200eCOVID\u201019)\u200e: situation report\u201094; cited 2021 December 12. 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