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To investigate the pathogenesis of worsening respiratory symptoms after A(H1N1)pdm09 infection, we focused on matrix metalloproteinase\u20109 (MMP\u20109) and tissue inhibitor of metalloproteinases\u20101 (TIMP\u20101). MMP\u20109 and TIMP\u20101 levels in bronchoalveolar lavage fluid and serum from mice with and without asthma were evaluated after A(H1N1)pdm09 or seasonal A(H1N1) infection. MMP\u20109 levels were more elevated in Asthma\/A(H1N1)pdm09\u2010infected mice than in non\u2010Asthma\/A(H1N1)pdm09\u2010infected mice on both 3 and 7 days post\u2010infection. Immunohistochemical findings in this pneumonia model showed that MMP\u20109 and TIMP\u20101 positive cells were observed in blood vessels and bronchus of lung tissue in severe pathological findings of pneumonia with asthma. Microscopically, shedding cells and secretions were conspicuous in the trachea on days 3 and 7 post\u2010infection, in the A(H1N1)pdm09\u2010infected mice with asthma. Our results suggest that MMP\u20109 and TIMP\u20101 expressions are related to severe pneumonia in the A(H1N1)pdm09 infection with asthma, leading to cause epithelial cell shedding.<\/jats:p>","DOI":"10.1111\/pin.13268","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T10:53:24Z","timestamp":1662461604000},"page":"506-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Histological characteristics of matrix metalloproteinase\u20109 and tissue inhibitor of metalloproteinases\u20101 in asthmatic murine model during A(H1N1)pdm09 infection"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3103-1750","authenticated-orcid":false,"given":"Sasagu","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Pediatrics Yamaguchi University Graduate School of Medicine  Ube 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