{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:51:43Z","timestamp":1783122703341,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Respiratory epithelial adenomatoid hamartoma (REAH) is a benign lesion of the nasal cavity and paranasal sinuses. Here, we report the clinicopathological characteristics of REAH identified in 2065 cases with nasal\/paranasal polypoid lesions treated with endoscopic sinus surgery (ESS) at our hospital from 2008 to 2021. Cases including the olfactory area were reviewed and 50 patients of REAH were identified pathologically (50\/2065, 2.4%). The average age was 58.9 years old and the male\/female ratio was 45\/5. Grossly, REAH showed a whitish surface and elastic firm consistency. The histopathological characteristics included proliferation of small to medium\u2010sized glands composed of ciliated respiratory epithelium containing goblet cells; thickening of the basement membrane compared to that for inverted papilloma (9.6\u2009\u00b1\u20092.4 vs. 1.3\u2009\u00b1\u20091.6\u2009\u00b5m, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001); and no intra\u2010epithelial neutrophilic infiltration. Among the REAH cases, 81% were associated with sinonasal inflammatory polyps. Many olfactory cleft polyps were REAH (38\/98, 39%). The rate of REAH found in ESS in the last 7 years was higher than that in the first 7 years (3.17% vs. 1.62%, <jats:italic>p<\/jats:italic>\u2009=\u20090.032). Our results in Japanese patients are similar to those found in other countries, including male predominance. REAH is relatively common and that 39% of polyps taken from olfactory clefts are REAH.<\/jats:p>","DOI":"10.1111\/pin.13271","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T14:30:15Z","timestamp":1663165815000},"page":"541-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Respiratory epithelial adenomatoid hamartomas of the sinonasal tract: A histopathological analysis of 50 patients"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0943-4115","authenticated-orcid":false,"given":"Masamichi","family":"Goto","sequence":"first","affiliation":[{"name":"Department of Pathology National Hospital Organization Kagoshima Medical Center Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Nishimoto","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology National Hospital Organization Kagoshima Medical Center Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyo","family":"Jougasaki","sequence":"additional","affiliation":[{"name":"Department of Pathology National Hospital Organization Kagoshima Medical Center Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology National Hospital Organization Kagoshima Medical Center Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuharu","family":"Nomoto","sequence":"additional","affiliation":[{"name":"Department of Pathology National Hospital Organization Kagoshima Medical Center Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(74)90397-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400809"},{"key":"e_1_2_8_4_1","volume-title":"Pathology and genetics of head and neck tumours","author":"Wenig B","year":"2005"},{"key":"e_1_2_8_5_1","first-page":"31","volume-title":"WHO classification of head and neck tumours","author":"Wenig B","year":"2017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22696"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480260000085"},{"key":"e_1_2_8_8_1","first-page":"E29","article-title":"Recurrent chondro\u2010osseous respiratory epithelial adenomatoid hamartoma of the nasal cavity in a child","volume":"93","author":"Nomura K","year":"2014","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12644"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22298"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22399"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3905"},{"key":"e_1_2_8_14_1","unstructured":"HuntJ BellD SariogluSSinonasal papillomas. In: El\u2010Naggar A Chan J Grandis J Takata T editors. WHO classification of head and neckt.2017. p.28\u201331."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1713-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3345"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.7162\/S1809-97772013000200017"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-012-0339-6"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000967"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200007000-00001"},{"key":"e_1_2_8_21_1","first-page":"200","article-title":"Localization and distribution of human olfactory mucosa in the nasal cavities","volume":"26","author":"Escada P","year":"2013","journal-title":"Acta Med Port"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2017.01.009"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2019.07.002"},{"key":"e_1_2_8_24_1","first-page":"3","article-title":"A rare case of porocarcinoma and trichoblastoma arising in a nevus sebaceus of Jadassohn","volume":"2021","author":"Mitchell DC","year":"2021","journal-title":"Case Rep Dermatol Med"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213344.55605.77"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2019.09.018"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514641"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181874ee8"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pin.13271","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T08:17:37Z","timestamp":1692692257000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.13271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,14]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/pin.13271"],"URL":"https:\/\/doi.org\/10.1111\/pin.13271","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,14]]},"assertion":[{"value":"2022-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}