{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:48:20Z","timestamp":1784198900120,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010655","name":"Tokai University","doi-asserted-by":"publisher","award":["2021 Tokai University School of Medicine Research"],"award-info":[{"award-number":["2021 Tokai University School of Medicine Research"]}],"id":[{"id":"10.13039\/501100010655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diffuse large B\u2010cell lymphoma (DLBCL) is the most common type of B\u2010cell lymphoma. Although the multilobated subtype of DLBCL has been observed since the 1970s, little is known about the clinical significance of this unique variant in the era of rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin, prednisone\/prednisolone (R\u2010CHOP) therapy. In this study, the retrospective clinicopathological analysis of 312 patients diagnosed with DLBCL showed that the multilobated DLBCL group comprised 11% of the cases and was predominantly male (<jats:italic>p<\/jats:italic>\u2009=\u20090.027), achieved complete remission in the first therapy (<jats:italic>p<\/jats:italic>\u2009=\u20090.023), and exhibited germinal center B\u2010cell phenotypes in the Hans algorithm (<jats:italic>p<\/jats:italic>\u2009=\u20090.025). The multilobated DLBCL groups had a better prognosis in overall survival (OS) and progression\u2010free survival (PFS) than the non\u2010multilobated DLBCL group (OS, <jats:italic>p<\/jats:italic>\u2009=\u20090.006; PFS, <jats:italic>p<\/jats:italic>\u2009=\u20090.010). In the multivariate Cox regression analyses for OS, independent prognosis factors were high soluble IL\u20102 receptor (<jats:italic>p<\/jats:italic>\u2009=\u20090.025), high risk of International Prognostic Index, and multilobated morphology (<jats:italic>p<\/jats:italic>\u2009=\u20090.031). The most characteristic copy number gains found in more than 50% of the cases were located at 1q, 3p, 10q, 12q, and 14q. Overall, the multilobated morphology in DLBCL exhibits a good outcome in the R\u2010CHOP era.<\/jats:p>","DOI":"10.1111\/pin.13280","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T11:39:12Z","timestamp":1665488352000},"page":"550-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The multilobated morphology is still a better prognosis factor of diffuse large B\u2010cell lymphoma in the R\u2010CHOP era"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3482-2742","authenticated-orcid":false,"given":"Atsushi","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Medicine Tokai University Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0751-5408","authenticated-orcid":false,"given":"Masashi","family":"Miyaoka","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Tokai University Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakura","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Tokai University Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Ikoma","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Tokai University Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Hiraiwa","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Tokai University Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-8299","authenticated-orcid":false,"given":"Joaquim","family":"Carreras","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Tokai University Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara Yukie","family":"Kikuti","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Tokai University Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kawada","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, School of Medicine Tokai University Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Tokai University Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"291","volume-title":"WHO classification of tumors of haematopoietic and lymphoid tissues, revised","author":"Gascoyne RD","year":"2017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008265532487"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2508"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-440073"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304083281404"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011795"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.5714"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.60.2383"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19841015)54:8<1598::AID-CNCR2820540822>3.0.CO;2-X"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850501)55:9<1913::AID-CNCR2820550914>3.0.CO;2-R"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900030202"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19851001)56:7<1578::AID-CNCR2820560719>3.0.CO;2-L"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80131-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1986.tb02513.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880401)61:7<1371::AID-CNCR2820610716>3.0.CO;2-G"},{"key":"e_1_2_9_19_1","first-page":"276","article-title":"Primary multilobated B cell lymphoma of the kidney: report of two cases","volume":"6","author":"Leoncini L","year":"1988","journal-title":"Appl Pathol"},{"key":"e_1_2_9_20_1","first-page":"28","article-title":"Multilobated B\u2010cell lymphoma. 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