{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:25:24Z","timestamp":1785684324742,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102020R1A4A4079708"],"award-info":[{"award-number":["NRF\u20102020R1A4A4079708"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102021R1C1C1005392"],"award-info":[{"award-number":["NRF\u20102021R1C1C1005392"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The diagnostic role of preferentially expressed antigen in melanoma (PRAME) immunohistochemistry has not been thoroughly evaluated for acral melanocytic tumors. The objective of this study was to evaluate the utility of this modality for the diagnosis of acral melanocytic tumors compared with other potential markers. Melanocytic tumors were classified as either acral nevi, challenging melanocytic tumors (superficial atypical melanocytic proliferation of uncertain significance (SAMPUS)\u2010favor benign (SAMPUS\u2010FB), SAMPUS\u2010favor malignant (SAMPUS\u2010FM)) or acral melanomas. A total of 106 acral melanocytic tumors including acral nevi (<jats:italic>n<\/jats:italic>\u2009=\u200932), SAMPUS\u2010FB (<jats:italic>n<\/jats:italic>\u2009=\u200917), SAMPUS\u2010FM (<jats:italic>n<\/jats:italic>\u2009=\u200920), and acral melanomas (<jats:italic>n<\/jats:italic>\u2009=\u200937) were included. Diagnostic power, assessed using an area under the receiver operating characteristic curve (AUC) for distinguishing acral melanomas and acral nevi, was highest for PRAME (AUC\u2009=\u20090.997), followed by c\u2010Myc (AUC\u2009=\u20090.755), cyclin D1 (AUC\u2009=\u20090.652), and c\u2010Kit (AUC\u2009=\u20090.573). At a PRAME expression level \u226530% as a positive test for acral melanoma, the sensitivity and specificity of this marker for discriminating acral melanoma from acral nevus were 100% and 96.9%, respectively. PRAME immunohistochemistry also discriminated SAMPUS\u2010FM from SAMPUS\u2010FB with a sensitivity and specificity of 90.0% and 76.5%, respectively. In conclusion, PRAME immunohistochemistry can be used effectively to distinguish between various spectra of acral melanocytic neoplasms.<\/jats:p>","DOI":"10.1111\/pin.13292","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T13:58:35Z","timestamp":1670248715000},"page":"27-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Performance of PRAME immunohistochemistry compared with that of c\u2010Kit, c\u2010Myc, or cyclin D1 for the diagnosis of acral melanocytic tumors"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-8306","authenticated-orcid":false,"given":"Joon Min","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong Hyun","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Eun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Asan Medical Center University of Ulsan College of Medicine  Seoul 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