{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:40:46Z","timestamp":1772131246835,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["20K17072"],"award-info":[{"award-number":["20K17072"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multisystem inflammatory syndrome in children (MIS\u2010C), which is associated with the novel coronavirus disease 2019 (COVID\u201019), has been described as an inflammatory complication of exposure to the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102). It carries a risk of serious and lethal complications, including cardiogenic shock. Here, we report the pathological findings of the pericardium in a 10\u2010year\u2010old child with MIS\u2010C, who developed pericarditis\u2010induced cardiac tamponade. In the patient's pericardium, the numbers of infiltrating CD68<jats:sup>+<\/jats:sup> macrophages; CD3<jats:sup>+<\/jats:sup>, CD4<jats:sup>+<\/jats:sup>, and CD8<jats:sup>+<\/jats:sup> T cells; and myeloperoxidase<jats:sup>+<\/jats:sup> granulocytes were increased, although the number of CD20<jats:sup>+<\/jats:sup> B cells was not. These findings provide a clue to understanding the pathophysiology of MIS\u2010C.<\/jats:p>","DOI":"10.1111\/pin.13304","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T08:41:00Z","timestamp":1672216860000},"page":"91-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Histopathological findings of pericarditis in a patient with multisystem inflammatory syndrome in children associated with COVID\u201019: A case report"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3935-328X","authenticated-orcid":false,"given":"Kazuaki","family":"Maruyama","sequence":"first","affiliation":[{"name":"Department of Pathology and Matrix Biology, Graduate School of Medicine Mie University  Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Aichi Children's Health and Medical Centre  Obu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Aichi Children's Health and Medical Centre  Obu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8919-7342","authenticated-orcid":false,"given":"Kyoko","family":"Imanaka\u2010Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pathology and Matrix Biology, Graduate School of Medicine Mie University  Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Center for Disease Control and Prevention.Information for healthcare providers about multisystem inflammatory syndrome in children (MIS\u2010C).2022. Available from:https:\/\/www.cdc.gov\/mis-c\/hcp\/"},{"key":"e_1_2_10_3_1","unstructured":"World Health Organization.Multisystem inflammatory syndrome in children and adolescents temporally related to COVID\u201019: scientific brief.2022. Available from:https:\/\/www.who.int\/news-room\/commentaries\/detail\/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00459-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-020-03292-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002700"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15270"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002660"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31103-X"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(20)30257-1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.24110\/0031-403X-2020-99-6-119-126"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa664"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21962"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13304","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pin.13304","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13304","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T13:40:34Z","timestamp":1692279634000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.13304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,28]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/pin.13304"],"URL":"https:\/\/doi.org\/10.1111\/pin.13304","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,28]]},"assertion":[{"value":"2022-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}