{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:57Z","timestamp":1787015877354,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ciliated muconodular papillary tumor\/bronchiolar adenoma (CMPT\/BA) is a recently introduced benign lung tumor. It remains unclear whether CMPT\/BA is associated with a specific type of lung cancer (LC). We studied the clinicopathological characteristics and genetic profiles of the coexisting primary LC and CMPT\/BA (LCCM) cases. We identified eight LCCM (0.4%) from the resected Stage 0\u2013III primary LC (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091945). The LCCM cohort was male\u2010dominant (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098), elderly (median 72 years old), and most were smokers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096). In addition to the adenocarcinoma (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098), we detected two squamous cell carcinomas and one small cell carcinoma\u2014in some cases, multiple cancer. The target sequence\/whole exome sequence (WES) revealed no shared mutations between CMPT\/BA and LC. One exceptional case was invasive mucinous adenocarcinoma harboring an\n                    <jats:italic>HRAS<\/jats:italic>\n                    mutation (I46N, c.137T&gt;A), but it was likely to be a single nucleotide polymorphism based on variant allele frequency (VAF). Other driver mutations in LC included\n                    <jats:italic>EGFR<\/jats:italic>\n                    (InDel,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092),\n                    <jats:italic>BRAF<\/jats:italic>\n                    (V600E) (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091),\n                    <jats:italic>KRAS<\/jats:italic>\n                    (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092),\n                    <jats:italic>GNAS<\/jats:italic>\n                    (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091), and\n                    <jats:italic>TP53<\/jats:italic>\n                    (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092).\n                    <jats:italic>BRAF<\/jats:italic>\n                    (V600E) was the most frequent mutation in CMPT\/BA (60%). In contrast, LC showed no specific trend in driver gene mutations. In conclusion, our study revealed differences in the gene mutation profiles of CMPT\/BA and LC in coexisting cases, suggesting mostly independent clonal tumorigenesis of CMPT\/BA from LC.\n                  <\/jats:p>","DOI":"10.1111\/pin.13316","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T02:26:06Z","timestamp":1678415166000},"page":"188-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinicopathological characteristics and molecular analysis of lung cancer associated with ciliated muconodular papillary tumor\/bronchiolar adenoma"],"prefix":"10.1111","volume":"73","author":[{"given":"Masahiro","family":"Higashiyama","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery National Cancer Center Hospital  Tokyo Japan"},{"name":"Course of Advanced Clinical Research of Cancer Juntendo University Graduate School of Medicine Bunkyo\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7098-3311","authenticated-orcid":false,"given":"Noriko","family":"Motoi","sequence":"additional","affiliation":[{"name":"Division of Genome Biology National Cancer Center Research Institute Chuo\u2010ku Tokyo Japan"},{"name":"Department of Diagnostic Pathology National Cancer Center Hospital Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Yotsukura","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigehiro","family":"Yagishita","sequence":"additional","affiliation":[{"name":"Division of Molecular Pharmacology National Cancer Center Research Institute Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Shirasawa","sequence":"additional","affiliation":[{"name":"Division of Genome Biology National Cancer Center Research Institute Chuo\u2010ku Tokyo Japan"},{"name":"Department of Thoracic Oncology National Cancer Center Hospital Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology National Cancer Center Hospital Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouya","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Division of Genome Biology National Cancer Center Research Institute Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kohno","sequence":"additional","affiliation":[{"name":"Division of Genome Biology National Cancer Center Research Institute Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Ohe","sequence":"additional","affiliation":[{"name":"Course of Advanced Clinical Research of Cancer Juntendo University Graduate School of Medicine Bunkyo\u2010ku Japan"},{"name":"Department of Thoracic Oncology National Cancer Center Hospital Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun\u2010ichi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"964","article-title":"Ciliated muconodular papillary tumor of the peripheral lung: benign or malignant?","volume":"9","author":"Ishikawa Y","year":"2002","journal-title":"Pathol Clin Med"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000414"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000707"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-017-0651-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2015.10.021"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjw144"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001086"},{"key":"e_1_2_11_9_1","unstructured":"WHO Classification of Tumours Editorial Board. 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