{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:49:00Z","timestamp":1782236940170,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K07012"],"award-info":[{"award-number":["JP18K07012"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP26253021"],"award-info":[{"award-number":["JP26253021"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Abnormalities of the AT\u2010rich interaction domain 1A (ARID1A) occur in cancer tissues and precursors or premalignant lesions in various organs. To investigate the significance of ARID1A abnormalities in the early phase of cancer development in the stomach, we screened for ARID1A loss and p53 overexpression in glands in non\u2010neoplastic gastric mucosa using immunohistochemistry. We tested 230 tissue blocks of 77 patients with gastric carcinoma, and in 10% of non\u2010neoplastic mucosa we detected ARID1A\u2010lost and in 3.7% p53\u2010overexpressed foci. Loss of ARID1A expression occurred in the scales of several glands, which were morphologically characterized as authentic, pseudo\u2010pyloric, or intestinal metaplastic glands devoid of dysplastic changes. In contrast, p53\u2010overexpressed foci were detected in dysplastic intestinal metaplasia. In early gastric cancer cases (<jats:italic>n<\/jats:italic>\u2009=\u200946), ARID1A\u2010lost foci were frequent in samples of patients with Epstein\u2013Barr virus\u2010associated gastric carcinoma (<jats:italic>p<\/jats:italic>\u2009=\u20090.037). Ultra\u2010deep DNA sequencing of ARID1A\u2010lost foci revealed frameshift and nonsense mutations in <jats:italic>ARID1A<\/jats:italic>. Mapping abnormal glands in the entire resected stomach of the three selected patients demonstrated that ARID1A\u2010lost foci clustered with p53 abnormal glands. ARID1A\u2010lost epithelial cells may develop clonal growth through the pathway, different from p53\u2010abnormal intestinal metaplasia, and require one or more events to develop into an overt carcinoma, such as EBV infection.<\/jats:p>","DOI":"10.1111\/pin.13320","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T13:18:27Z","timestamp":1680614307000},"page":"234-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lost expression of AT\u2010rich interaction domain 1A in the gastric mucosa\u2014A constituent of field cancerization in the stomach"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4513-1007","authenticated-orcid":false,"given":"Hiroyuki","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Pathology, Graduate School of Medicine The University of Tokyo Tokyo 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