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The present study aimed to clarify the clinicopathological features, molecular classification, and programmed death\u2010ligand 1 (PD\u2010L1) expression characteristics of papillary adenocarcinoma, especially tumors with microsatellite instability. We examined the microsatellite status and expression of mucin core proteins and PD\u2010L1 as well as the clinicopathological features in 40 gastric papillary adenocarcinomas. Surrogate immunohistochemical analysis of p53 and mismatch repair proteins along with Epstein\u2010Barr virus\u2010encoded RNA in situ hybridization were performed for molecular classification. Female predominance and frequent microsatellite instability were observed in papillary adenocarcinoma in comparison with tubular adenocarcinoma. The presence of microsatellite instability in papillary adenocarcinoma was significantly correlated with older age, tumor\u2010infiltrating lymphocytes, and Crohn's\u2010like lymphoid reactions. Surrogate examination demonstrated that the genomically stable type (17 cases, 42.5%) was the most common, followed by the microsatellite\u2010unstable type (14 cases, 35%). Among the seven cases showing PD\u2010L1\u2010positive expression in tumor cells, four involved carcinomas with microsatellite instability. These results reveal the clinicopathological and molecular characteristics of gastric papillary adenocarcinoma.<\/jats:p>","DOI":"10.1111\/pin.13345","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T14:12:54Z","timestamp":1687356774000},"page":"358-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinicopathological and molecular characteristics of gastric papillary adenocarcinoma"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4583-8301","authenticated-orcid":false,"given":"Tomio","family":"Arai","sequence":"first","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Institute for Geriatrics and Gerontology Tokyo 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