{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:32:28Z","timestamp":1784759548982,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is an immune cell\u2010dependent chronic autoimmune skin disorder. Interleukin 37 (IL\u201037) is a cytokine belonging to the IL\u20101 family that shows anti\u2010inflammatory and protective effects in various mouse models of psoriasis. Even though various animal models are used to investigate the pathogenic mechanisms of psoriasis, human clinical studies are still needed to make up for the deficiencies, as animal models generally do not exhibit the complex phenotypic features of human psoriasis. Our study aims to demonstrate the relationship between IL\u201037\u2010producing tissue\u2010resident immune cells with the pathogenesis of psoriasis. The present study was performed on 28 psoriasis patients and 17 healthy volunteers. The ability of anti\u2010inflammatory cytokine IL\u201037 to impede inflammation and regulate metabolic pathways was assessed by real\u2010time quantitative polymerase chain reaction. Finally, immunofluorescence double staining for CD4<jats:sup>+<\/jats:sup>IL\u201037b<jats:sup>+<\/jats:sup>, CD68<jats:sup>+<\/jats:sup>IL\u201037b<jats:sup>+<\/jats:sup>, and (forkhead box protein P3) Foxp3<jats:sup>+<\/jats:sup>IL\u201037b<jats:sup>+<\/jats:sup> was performed. The proportion of CD4<jats:sup>+<\/jats:sup>IL\u201037b<jats:sup>+<\/jats:sup> T cells, CD68<jats:sup>+<\/jats:sup>IL\u201037b<jats:sup>+<\/jats:sup> macrophages, and Foxp3<jats:sup>+<\/jats:sup>IL\u201037b<jats:sup>+<\/jats:sup> T regulatory (Treg) cells was significantly increased in the psoriasis group compared to the control group. IL\u201037 gene expression was downregulated in psoriasis when contrasted to the control group. Our findings disclosed that IL\u201037\u2010producing tissue\u2010resident immune cells might be involved in the pathogenesis of psoriasis, and thus may be a therapeutic target for individuals with psoriasis.<\/jats:p>","DOI":"10.1111\/pin.13364","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T04:50:24Z","timestamp":1692420624000},"page":"490-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lowered IL\u201037 gene expression and elevated IL\u201037\u2010producing tissue\u2010resident immune cells in psoriasis lesional biopsies"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5945-0725","authenticated-orcid":false,"given":"Aini","family":"Wulamujiang","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Hamidiye International School of Medicine University of Health Sciences Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3357-1059","authenticated-orcid":false,"given":"Seyma","family":"Ozkanli","sequence":"additional","affiliation":[{"name":"Department of Pathology Goztepe Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1003-5544","authenticated-orcid":false,"given":"Ender","family":"Coskunpinar","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Hamidiye School of Medicine University of Health Sciences Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4671-1249","authenticated-orcid":false,"given":"Halime Tuba","family":"Canbaz","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Hamidiye School of Medicine University of Health Sciences Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3375-8956","authenticated-orcid":false,"given":"Gamze","family":"Yesilay","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Hamidiye Institute of Health Science University of Health Sciences Istanbul Turkey"},{"name":"Experimental Medicine Application &amp; 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