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Although previous studies have reported obvious differences in the frequency of Lewy body pathology (LBP) in the CP, none of them have confirmed whether LBP preferably appears in any part of the CP. Thus, we aimed to clarify the emergence and\/or propagation of LBP in the CP. In this study, 263 consecutive autopsy cases of patients aged \u226550 years were included, with one region per case selected from three myocardial perfusion areas (MPAs) and subjected to proteinase K and then immunohistochemically stained with anti\u2010\u03b1\u2010synuclein antibodies to assess LBP. We stained all three MPAs in 17 cases with low\u2010density LBP and observed the actual distribution of LBP. LBP were identified in the CP in 20.2% (53\/263) of patients. Moreover, we found that LBP may appear in only one region of MPAs, mainly in the young\u2010old group (35.3% (6\/17) of patients). These findings suggest that it is possible to underestimate LBP in the CP, especially in the young\u2010old group, by restricting the search to only one of the three MPAs.<\/jats:p>","DOI":"10.1111\/pin.13389","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T13:57:40Z","timestamp":1701439060000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distribution of proteinase K\u2010resistant anti\u2010\u03b1\u2010synuclein immunoreactive axons in the cardiac plexus is unbiased to the left ventricular anterior wall"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1942-3586","authenticated-orcid":false,"given":"Nei","family":"Fukasawa","sequence":"first","affiliation":[{"name":"Department of Pathology The Jikei University School of Medicine  Tokyo 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