{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:05:57Z","timestamp":1791655557724,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["20FC1022"],"award-info":[{"award-number":["20FC1022"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical presentation of systemic amyloidosis differs among subtypes, and accurate subtype classification is important for choosing the treatment. Amyloid transthyretin (ATTR) amyloidosis was the predominant among the recently consulted amyloidosis cases in Japan. To reveal the latest subtype frequency of systemic amyloidosis among autopsy cases in Japan. We analyzed systemic amyloidosis cases autopsied from January 2017 to December 2018, that were listed in the Annuals of the Pathological Autopsy Cases in Japan, Volumes 60 and 61. When the subtype was unclear, we performed a questionnaire survey, immunohistochemistry with in\u2010house rabbit polyclonal anti\u2010\u03ba<jats:sub>116<\/jats:sub><jats:sub>\u2013<\/jats:sub><jats:sub>133<\/jats:sub>, anti\u2010\u03bb<jats:sub>118<\/jats:sub><jats:sub>\u2013134<\/jats:sub>, and anti\u2010transthyretin<jats:sub>115<\/jats:sub><jats:sub>\u2013124<\/jats:sub> antibodies, and proteomic analysis. Out of 481 systemic amyloidosis cases listed in the Annuals, 411 cases were available for analysis (85.4%). We classified 399 of these systemic amyloidosis cases. ATTR was the most common subtype (44.4%, <jats:italic>n<\/jats:italic>\u2009=\u2009177), followed by amyloid immunoglobulin light chain (AL) (38.8%, <jats:italic>n<\/jats:italic>\u2009=\u2009155). Amyloid A and amyloid \u03b2<jats:sub>2<\/jats:sub>\u2010microglobulin were 9.3% (<jats:italic>n<\/jats:italic>\u2009=\u200937) and 6.0% (<jats:italic>n<\/jats:italic>\u2009=\u200924), respectively. Double deposition of amyloid was identified in 1.6% (<jats:italic>n<\/jats:italic>\u2009=\u20096). In 168 cases (42.1%), systemic amyloidosis was the main cause of death. Of these cases, AL was the most common subtype (47.6%, <jats:italic>n<\/jats:italic>\u2009=\u200980), followed by ATTR (41.1%, <jats:italic>n<\/jats:italic>\u2009=\u200969). ATTR is the most predominant subtype among the current autopsy cases in Japan.<\/jats:p>","DOI":"10.1111\/pin.13395","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T13:17:23Z","timestamp":1702473443000},"page":"68-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Epidemiological study of the subtype frequency of systemic amyloidosis listed in the Annual of the Pathological Autopsy Cases in Japan"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4895-213X","authenticated-orcid":false,"given":"Aina","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Molecular Pathology University of Fukui Fukui Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9597-4128","authenticated-orcid":false,"given":"Masayoshi","family":"Tasaki","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medical Sciences Kumamoto University  Kumamoto Japan"},{"name":"Department of Biomedical Laboratory Sciences, Graduate School of Health Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6814-0582","authenticated-orcid":false,"given":"Mitsuharu","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medical Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Amyloidosis Research Nagasaki International University  Sasebo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7735-4382","authenticated-orcid":false,"given":"Hironobu","family":"Naiki","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology University of Fukui Fukui Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12902"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506696"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13169"},{"key":"e_1_2_10_5_1","first-page":"159","article-title":"Amyloidosis\u2014the diagnosis and treatment of an underdiagnosed disease","volume":"117","author":"Ihne S","year":"2020","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1994.tb02935.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050211"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-358507"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01274-X"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2023.2180334"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2021.153635"},{"issue":"5","key":"e_1_2_10_12_1","first-page":"460","article-title":"Epidemiology of amyloidosis","volume":"34","author":"Ueda M","year":"2016","journal-title":"Pathol Clin Med"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2001.01198.x"},{"issue":"6","key":"e_1_2_10_14_1","first-page":"1301","article-title":"Mechanisms of transthyretin amyloidogenesis. Antigenic mapping of transthyretin purified from plasma and amyloid fibrils and within in situ tissue localizations","volume":"144","author":"Gustavsson A","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-230722"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5203"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606379103"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31491-5"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T11:57:03Z","timestamp":1707998223000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.13395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/pin.13395"],"URL":"https:\/\/doi.org\/10.1111\/pin.13395","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,13]]},"assertion":[{"value":"2023-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}