{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T10:30:15Z","timestamp":1742380215492,"version":"3.37.3"},"reference-count":81,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Perturbation of genes is important for somatic hypermutation to increase antibody affinity during B\u2010cell immunity; however, it may also promote carcinogenesis. Previous studies have revealed that transcription is an important process that can induce DNA damage and genomic instability. Transciption\u2010export\u20102 (TREX\u20102) complex, which regulates messenger RNA (mRNA) nuclear export, has been studied in the budding yeast <jats:italic>Saccharomyces cerevisiae<\/jats:italic>; however, recent studies have started investigating the molecular function of the mammalian TREX\u20102 complex. The central molecule in the TREX\u20102 complex, that is, germinal center\u2010associated nuclear protein (GANP), is closely associated with antibody affinity maturation as well as cancer etiology. In this review, we focus on carcinogenesis, lymphomagenesis, and teratomagenesis caused by transcription\u2010coupled DNA damage through GANP and other components of the TREX\u20102 complex. We review the basic machinery of mRNA nuclear export and transcription\u2010coupled DNA damage. We then briefly describe the immunological relationship between GANP and the affinity maturation of antibodies. Finally, we illustrate that the aberrant expression of the components of the TREX\u20102 complex, especially GANP, is associated with the etiology of various solid tumors, lymphomas, and testicular teratoma. These components serve as reliable predictors of cancer prognosis and response to chemotherapy.<\/jats:p>","DOI":"10.1111\/pin.13415","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T13:05:51Z","timestamp":1709039151000},"page":"103-118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Carcinogenesis caused by transcription\u2010coupled DNA damage through GANP and other components of the TREX\u20102 complex"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-9249","authenticated-orcid":false,"given":"Yasuhiro","family":"Sakai","sequence":"first","affiliation":[{"name":"Department of Tumor Pathology Hamamatsu University School of Medicine Shizuoka Japan"},{"name":"Department of Joint Research Laboratory of Clinical Medicine Fujita Health University School of Medicine  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7739-2183","authenticated-orcid":false,"given":"Kazuhiko","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kindai University Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.17.7915"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geh025"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.76.061705.090740"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2020.08.007"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/121.4.659"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0061(199608)12:10<965::AID-YEA999>3.0.CO;2-Q"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.109.6.1575"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf590"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)01025-0"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1163"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200810059"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.7.2321"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(00)00336-X"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.10.078"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kvd009"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb773"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.118000"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.35.22177"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.12.035"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181335698"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/157.1.79"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302900200"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2003.08.010"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.7.2294"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2017.03.024"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2007.01119.x"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-071719-020312"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw018"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.72"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac151"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14563-y"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2015.4"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0034-3"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13829"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam7344"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2823"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307609100"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.9.5615"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.8.4485"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.041749"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.6b00006"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.7.4133"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1702903"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.2.673"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200649"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2010.01396.x"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3259"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12010204"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.12.007"},{"key":"e_1_2_12_51_1","first-page":"287","article-title":"Cholangiocarcinomas associated with long\u2010term inflammation express the activation\u2010induced cytidine deaminase and germinal center\u2010associated nuclear protein involved in immunoglobulin V\u2010region diversification","volume":"35","author":"Chan\u2010On W","year":"2009","journal-title":"Int J Oncol"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-012-0711-8"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15685"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12883"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-019-00956-5"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01293.x"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040201"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2004.08.004"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20537"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1566"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/50.1.235"},{"key":"e_1_2_12_62_1","first-page":"263","article-title":"Morphologic analysis of spontaneous teratocarcinogenesis in developing testes of strain 129\/Sv\u2010ter mice","volume":"124","author":"Rivers EN","year":"1986","journal-title":"Am J Pathol"},{"key":"e_1_2_12_63_1","first-page":"385","article-title":"A recessive mutation (ter) causing germ cell deficiency and a high incidence of congenital testicular teratomas in 129\/Sv\u2010ter mice","volume":"75","author":"Noguchi T","year":"1985","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv129"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1580"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08092-3"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(04)00256-4"},{"key":"e_1_2_12_68_1","first-page":"396","article-title":"p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest","volume":"58","author":"Khan SH","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_12_69_1","first-page":"1013","article-title":"DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function","volume":"57","author":"Di Leonardo A","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa555"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab308"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.884210"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs279"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2015.02.010"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08210-y"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-562"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-021-00613-6"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002026"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-023-01000-8"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.939948"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx138"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddaa051"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T11:50:54Z","timestamp":1710935454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.13415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,27]]},"references-count":81,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/pin.13415"],"URL":"https:\/\/doi.org\/10.1111\/pin.13415","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"type":"print","value":"1320-5463"},{"type":"electronic","value":"1440-1827"}],"subject":[],"published":{"date-parts":[[2024,2,27]]},"assertion":[{"value":"2023-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}