{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T13:51:24Z","timestamp":1777125084417,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Carcinoma showing thymus\u2010like elements (CASTLE) is a rare tumor that commonly occurs in the thyroid gland. Extrathyroidal CASTLE is rarer, and only 11 cases of CASTLE of major salivary glands have been reported to date. We report the first case of amyloid deposition in parotid CASTLE. A 63\u2010year\u2010old man presented with a slowly growing mass in the left parotid region. Computed tomography revealed an approximately 28\u2009\u00d7\u200923\u2009mm mass lesion in the left parotid gland, and squamous cell carcinoma was suspected on biopsy. The patient underwent a parotidectomy with neck dissection. Morphologically, the tumor cells were squamoid and formed nests with lymphoid infiltration. Immunohistochemically, the tumor cells exhibited immunoreactivity for CD5, CD117\/c\u2010kit\u00a0and Bcl\u20102, p40, and CK5 but not for p16. We diagnosed the tumor as parotid CASTLE. Amyloid deposition was also observed in the primary tumor and metastatic lymph node lesions, which were immunoreactive for cytokeratin 5. Tumor cytokeratin\u2010derived amyloid deposition may be one of characteristics of parotid CASTLE.<\/jats:p>","DOI":"10.1111\/pin.13420","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T06:31:08Z","timestamp":1710570668000},"page":"227-233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Carcinoma showing thymus\u2010like elements (CASTLE) with amyloid deposition in the parotid gland"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7952-3642","authenticated-orcid":false,"given":"Mei","family":"Hamada","sequence":"first","affiliation":[{"name":"Department of Pathology, Saitama International Medical Center Saitama Medical University Saitama Japan"},{"name":"Department of Diagnostic Pathology Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5901-6961","authenticated-orcid":false,"given":"Yu","family":"Miyama","sequence":"additional","affiliation":[{"name":"Department of Pathology, Saitama International Medical Center Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Saitama International Medical Center Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-6176","authenticated-orcid":false,"given":"Yukako","family":"Shintani\u2010Domoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Nippon Medical School Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Urano","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Bantane Hospital Fujita Health University School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Pathology, Saitama International Medical Center Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01656263"},{"key":"e_1_2_11_3_1","unstructured":"WHO Classification Of Tumours Editorial Board. Endocrine and neuroendocrine tumours [Internet]. International Agency for Research on Cancer;2022. \u00a0Accessed December 28 2023. (WHO classification of tumours series 5th ed.; vol. 10).https:\/\/tumourclassification.iarc.who.int\/chapters\/53"},{"key":"e_1_2_11_4_1","volume-title":"WHO classification of tumours of endocrine organs","author":"Lloyd RV","year":"2017"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24985"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896920941604"},{"issue":"1","key":"e_1_2_11_7_1","first-page":"384","article-title":"Ectopic thymic carcinoma in parotid gland: a rare case and review of literature","volume":"12","author":"Huang P","year":"2019","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00734"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02981-8"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-021-01394-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2022.02.013"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2021.153646"},{"key":"e_1_2_11_13_1","article-title":"Expression of CD5 in salivary gland tumors: an ancillary marker for carcinoma showing thymus\u2010like differentiation (CASTLE) of the major salivary gland","author":"Sasaki E","journal-title":"Virchows Arch"},{"key":"e_1_2_11_14_1","volume-title":"WHO classification of head and neck tumours","author":"El\u2010Naggar AK","year":"2017"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.25088"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.06.014"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-020-01172-w"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2019.02.016"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31823465c7"},{"key":"e_1_2_11_19_2","unstructured":"Quiz15\u201317."},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70156-C"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-015-9390-7"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T13:32:05Z","timestamp":1712755925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.13420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,15]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/pin.13420"],"URL":"https:\/\/doi.org\/10.1111\/pin.13420","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,15]]},"assertion":[{"value":"2024-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}