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A case series involving multifocal thyroid lesions with divergent histopathological morphology and\/or molecular profile, with molecular evaluation of multiple individual tumor foci per patient based on a next\u2010generation sequencing approach, was retrospectively reviewed. Twenty\u2010five patient cases with multifocal thyroid lesions suggestive of MUF, with 2\u20136 (median 3) tumor foci per patient, were described. Tumor lesions comprised diverse histopathology, including PTC, (E)FVPTC, NIFTP, FA, FTC, and oncocytic. Morphologically similar and\/or diverse tumor foci harbored different molecular alterations (suggestive of non\u2010shared clonality); with(out) coexistent similar foci harboring identical molecular alterations; or (partly) shared molecular alterations. MUF was associated with chronic lymphocytic thyroiditis in almost half of the cases. The recognition of MUF may justify the independent clinical consideration per individual tumor focus; as separate lesions albeit within a multifocal context. The potential clinical relevance and prognostic value of MUF remain to be further established.<\/jats:p>","DOI":"10.1111\/pin.13421","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T13:34:49Z","timestamp":1711978489000},"page":"274-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multi\u2010UniFocality (MUF), in contrast to multifocality, in thyroid lesions: Relation to lymphocytic thyroiditis"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2891-7059","authenticated-orcid":false,"given":"Mehtap Derya","family":"Aydemirli","sequence":"first","affiliation":[{"name":"Department of Pathology Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Morreau","sequence":"additional","affiliation":[{"name":"Department of Pathology Leiden University Medical Center 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