{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:12:10Z","timestamp":1776409930223,"version":"3.51.2"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We herein report a case of methotrexate\u2010associated lymphoproliferative disorder (MTX\u2010LPD) showing fibrin\u2010associated large B\u2010cell lymphoma\u2010like heart valve lesions, and Epstein\u2010Barr virus (EBV)\u2010positive mucocutaneous ulcer\u2010like cutaneous and oral mucosal lesions. MTX\u2010LPD is a critical complication that can occur in RA patients who are treated with MTX. EBV also plays a defining or important role in LPDs. Among the sites of MTX\u2010LPD, 40\u221250% occur in extranodal sites, including the gastrointestinal tract, skin, liver, lung, and kidney. There are few reports of MTX\u2010LPDs involving the heart valves, and to the best of our knowledge, this is the first case to be reported in the English literature. The possibility of EBV\u2010positive LPD should be considered in RA patients, even in patients with an atypical site, as in this case.<\/jats:p>","DOI":"10.1111\/pin.13424","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T15:48:16Z","timestamp":1712072896000},"page":"285-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Polymorphic lymphoproliferative disorder arising in a rheumatoid arthritis patient, presenting as fibrin\u2010associated large B\u2010cell lymphoma\u2010like lesions in aortic and mitral valves"],"prefix":"10.1111","volume":"74","author":[{"given":"Hideaki","family":"Tsujii","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Japanese Red Cross Wakayama Medical Center Wakayama Japan"},{"name":"Department of Diagnostic Pathology Kyoto University Hospital Sakyo\u2010ku Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4268-571X","authenticated-orcid":false,"given":"Ryuko","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Japanese Red Cross Wakayama Medical Center Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohei","family":"Funakoshi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Japanese Red Cross Wakayama Medical Center Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Japanese Red Cross Wakayama Medical Center Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4322-9561","authenticated-orcid":false,"given":"Hironori","family":"Haga","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital Sakyo\u2010ku Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Japanese Red Cross Wakayama Medical Center Wakayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001271"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_8_4_1","volume-title":"WHO Classification of Tumours Editorial Board. Haematolymphoid tumours [Internet; beta version ahead of print]","author":"Natkunam Y","year":"2022"},{"key":"e_1_2_8_5_1","volume-title":"WHO Classification of Tumours Editorial Board. Haematolymphoid tumours [Internet; beta version ahead of print]","author":"Natkunam Y","year":"2022"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.19028"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-017-3764-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-021-01849-8"},{"key":"e_1_2_8_9_1","volume-title":"WHO Classification of Tumours Editorial Board. 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