{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T09:51:29Z","timestamp":1756893089605,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nodal T\u2010follicular helper cell lymphoma (TFHL) is a subset of T\u2010cell lymphoma and frequently co\u2010occurs with Epstein\u2013Barr virus (EBV)\u2010positive B\u2010cell lymphoma but not with T\/NK\u2010cell lymphoma. Recently, a new entity with a worse prognosis, called EBV\u2010positive nodal T\/NK\u2010cell lymphoma (NTNKL) has been established. Here, we report an autopsy case of synchronous multiple lymphomas, including TFHL and NTNKL. The patient was a 78\u2010year\u2010old female admitted with pneumonia. Although pneumonic symptoms were improved, fever, pancytopenia, and disseminated intravascular coagulation emerged, implicating lymphoma. She died on the 21st hospital day without a definitive diagnosis. The autopsy revealed the enlargement of multiple lymph nodes throughout her body. Histological analysis revealed three distinct regions in the left inguinal lymph node. The first region consists of small\u2010sized lymphocytes with T\u2010follicular helper phenotype and extended follicular dendritic cell meshwork, indicating TFHL. The second region included EBV\u2010positive large B cells. The third region comprised EBV\u2010positive large cells with cytotoxic T\/NK cell phenotype, indicating NTNKL. Clonality analysis of the first and the third regions showed different patterns. Since various hematopoietic malignancies progress from common clonal hematopoiesis according to existing literature, this case may help to understand TFHL and NTNKL.<\/jats:p>","DOI":"10.1111\/pin.13425","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T13:18:36Z","timestamp":1712323116000},"page":"346-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Co\u2010occurrence of Epstein\u2013Barr virus\u2010positive nodal T\/NK\u2010cell lymphoma and nodal T\u2010follicular helper cell lymphoma of different clonal origins: An autopsy case report"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-1277","authenticated-orcid":false,"given":"Daisuke","family":"Hoshi","sequence":"first","affiliation":[{"name":"Department of Oncologic Pathology Kanazawa Medical University Ishikawa Japan"},{"name":"Department of Diagnostic Pathology Kanazawa University Hospital Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nami","family":"Migita","sequence":"additional","affiliation":[{"name":"School of Medicine Kanazawa Medical University Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Ishizawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Toyama Prefectural Central Hospital Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5234-6861","authenticated-orcid":false,"given":"Yasuharu","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Molecular Hematopathology Okayama University Graduate School of Health Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Yamamura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kanazawa Medical University Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0326-0479","authenticated-orcid":false,"given":"Etsuko","family":"Kiyokawa","sequence":"additional","affiliation":[{"name":"Department of Oncologic Pathology Kanazawa Medical University Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31802d68e9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.20001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-023-03616-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.280003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1452"},{"key":"e_1_2_10_8_1","article-title":"Epstein\u2010Barr virus\u2010positive adrenal diffuse large B\u2010cell lymphoma after treatment for angioimmunoblastic T\u2010cell lymphoma","volume":"8","author":"Hashimoto A","year":"2021","journal-title":"Eur J Case Rep Intern 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