{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:59Z","timestamp":1787015879232,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Clear cell hidradenoma is a rare benign tumor of the breast, its origin and pathogenesis are controversial. We have experienced a case of breast clear cell hidradenoma with mastermind like transcriptional coactivator 2 (\n                    <jats:italic>MAML2<\/jats:italic>\n                    ) gene rearrangement. The patient found a painless mass with a hard texture in the left breast areola without nipple discharge. Microscopically, the tumor was cystic and solid, locally arranged in a glandular structure, covered by single cuboidal cells; it was composed of clear cells, epidermoid cells, and basaloid cells; there were no necrosis or mitotic figures. Immunohistochemical staining showed that the tumor cells positively expressed low\u2010molecular cytokeratin 7, low\u2010molecular cytokeratins (Cam5.2), high\u2010molecular cytokeratin 5\/6, cytokeratin 14, CD117, and p63; and did not express calponin, and smooth muscle myosin heavy chain. The cuboidal cells were positive for SOX10 but negative for p63. Additionally, periodic acid\u2010Schiff reaction showed purple\u2010red granules in the tumor cytoplasm, but Alcian blue staining showed no blue mucus in the cytoplasm. The split signals of\n                    <jats:italic>MAML2<\/jats:italic>\n                    gene were detected by fluorescence in situ hybridization. Subtle histological and immunophenotypical differences may help to distinguish breast clear cell hidradenoma from common breast tumors. Furthermore, the\n                    <jats:italic>MAML2<\/jats:italic>\n                    gene rearrangement may be a molecular genetic characteristic of breast clear cell hidradenoma.\n                  <\/jats:p>","DOI":"10.1111\/pin.13455","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T06:45:59Z","timestamp":1717137959000},"page":"482-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clear cell hidradenoma of the breast with\n                    <i>MAML2<\/i>\n                    gene rearrangement"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7839-7878","authenticated-orcid":false,"given":"Li","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Pathology, Beijing Luhe Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Beijing Luhe Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"WHO Classification of Tumours Editorial Board. 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