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After PBSCT, hematological complete remission (HCR) can be achieved, leading to improved renal prognosis. The purpose of this study was to evaluate whether whole slide imaging of biopsy samples shows a post\u2010treatment reduction in amyloid deposits in patients with AL amyloidosis. Patients were divided into three groups: Group A (<jats:italic>n<\/jats:italic>\u2009=\u20098), not eligible for PBSCT and treated with other therapies; Group B (<jats:italic>n<\/jats:italic>\u2009=\u200911), treated with PBSCT and achieved HCR; and Group C (<jats:italic>n<\/jats:italic>\u2009=\u20095), treated with PBSCT but did not achieve HCR. Clinical findings and amyloid deposition in glomeruli, interstitium, and blood vessels were compared before and after treatment using digital whole\u2010slide imaging. Proteinuria and hypoalbuminemia improved more in Group B than in the other groups, and in Group B, amyloid deposition improved more in the glomeruli than in the interstitium and blood vessels. The long\u2010term renal and survival prognosis was better in Group B than in the other groups. PBSCT can be expected to improve long\u2010term clinical and renal histological prognosis in patients with AL amyloidosis who achieve HCR. Amyloid disappearance from renal tissue may take a long time even after clinical HCR.<\/jats:p>","DOI":"10.1111\/pin.13466","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T13:06:19Z","timestamp":1721221579000},"page":"508-519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Digital whole\u2010slide imaging of changes in amyloid after peripheral blood stem cell transplantation in patients with amyloid light\u2010chain amyloidosis"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5097-3538","authenticated-orcid":false,"given":"Kei","family":"Kono","sequence":"first","affiliation":[{"name":"Department of Pathology Toranomon Hospital Tokyo Japan"},{"name":"Department of Human Pathology Graduate School of Medicine, Tokyo Medical and Dental University Tokyo Japan"},{"name":"Okinaka Memorial Institute for Medical Research Toranomon Hospital Tokyo 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