{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:19:57Z","timestamp":1740125997910,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epstein\u2013Barr virus (EBV) is a major cause of infectious mononucleosis (IM), characterized by fever, fatigue, sore throat, lymphadenopathy, atypical lymphocytosis, and elevated liver enzymes. However, ascites is a rare complication associated with IM. We present a rare case of IM with ascites and peritonitis in a patient who underwent a peritoneal biopsy. A 20\u2010year\u2010old woman presented with fatigue and abdominal distension. Laboratory examination revealed atypical lymphocytes in peripheral blood (54%) and elevated liver enzymes. EBV serological tests revealed a recent primary infection (EBV VCA IgM 1:160). Computed tomography revealed moderate ascites and peritonitis. Adenocarcinoma was suspected based on the ascites' cytology. Considering possible complications of IM and adenocarcinoma, a laparoscopic biopsy was performed. Histological findings of biopsy specimens from the peritoneum, omentum, and fimbria of the fallopian tube demonstrated severe inflammatory cell infiltration and focal aggregation of large EBV\u2010encoded RNA\u20101 (EBER1)\u2010positive B cells, mimicking EBV\u2010positive polymorphous B\u2010cell lymphoproliferative disorder. Furthermore, intracytoplasmic inclusion bodies of <jats:italic>Chlamydia trachomatis<\/jats:italic> were observed by immunohistochemistry. Real\u2010time polymerase chain reaction detected <jats:italic>C. trachomatis<\/jats:italic> in cervical secretions. Two months after laparoscopy, ascites decreased, and the diagnosis was IM\u2010associated peritonitis with <jats:italic>C. trachomatis<\/jats:italic> infection. IM should be considered as a differential diagnosis in young patients with ascites.<\/jats:p>","DOI":"10.1111\/pin.13469","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T11:49:53Z","timestamp":1721994593000},"page":"611-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histopathology of peritonitis due to infectious mononucleosis with background <i>Chlamydia trachomatis<\/i> infection: A case report and literature review"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0606-7524","authenticated-orcid":false,"given":"Yuto","family":"Kaimi","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Naka","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7569-7813","authenticated-orcid":false,"given":"Hiroshi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Uno","sequence":"additional","affiliation":[{"name":"Department of Gynecology National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7251-7920","authenticated-orcid":false,"given":"Akiko Miyagi","family":"Maeshima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197507102930202"},{"key":"e_1_2_10_3_1","first-page":"87","article-title":"Primary Epstein\u2013Barr virus hepatitis complicated by ascites with Epstein\u2010Barr virus reactivation during primary cytomegalovirus infection","volume":"37","author":"Rajwal S","year":"2003","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/22953337.1983.11718929"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12953-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-2977(94)00053-C"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540410027148"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-232562"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2003.12.003"},{"key":"e_1_2_10_10_1","first-page":"808","article-title":"Exudative ascites complicating infectious mononucleosis","volume":"81","author":"Marano AR","year":"1986","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00806.x"},{"key":"e_1_2_10_12_1","first-page":"1781","article-title":"Chronic autoimmune hepatitis with Epstein\u2013Barr virus superinfection: a case report and review of literature","volume":"55","author":"Koay LB","year":"2008","journal-title":"Hepato\u2010gastroenterology"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis646"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.05.020"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00445-07"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.0445"},{"key":"e_1_2_10_17_1","first-page":"105","article-title":"Infectious mononucleosis mimicking malignant T\u2010cell lymphoma in the nasopharynx: a case report and review of the literature","volume":"6","author":"He HL","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.1999.01119.x"},{"key":"#cr-split#-e_1_2_10_19_1.1","doi-asserted-by":"crossref","unstructured":"TsutsumiY. Cytological diagnosis of infectious diseases: Identification of pathogens and recognition of cellular reactions. [updated 2021 Feb 9","DOI":"10.5772\/intechopen.95578"},{"key":"#cr-split#-e_1_2_10_19_1.2","unstructured":"cited 2024 Apr 11]. Available from:https:\/\/www.intechopen.com\/chapters\/75152"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-023-03660-5"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T15:07:30Z","timestamp":1728572850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.13469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,26]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/pin.13469"],"URL":"https:\/\/doi.org\/10.1111\/pin.13469","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"type":"print","value":"1320-5463"},{"type":"electronic","value":"1440-1827"}],"subject":[],"published":{"date-parts":[[2024,7,26]]},"assertion":[{"value":"2024-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}