{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T13:12:10Z","timestamp":1751461930291,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of adult T\u2010cell leukemia\/lymphoma (ATLL) with angioimmunoblastic T\u2010cell lymphoma (AITL\/nTFHL\u2010AI)\u2010like feature. An 88\u2010year\u2010old Japanese woman with seropositive for the Human T\u2010lymphotropic virus type 1 (HTLV\u20101) was incidentally diagnosed with generalized lymphadenopathy. Biopsy of the cervical lymph node demonstrated the proliferation of small\u2010 or medium\u2010sized and large atypical lymphocytes associated with eosinophils, high endothelial venules, and clear cells. Immunohistochemical analysis revealed atypical lymphocytes were CD3\u2010 and CD4\u2010positive. Atypical T cells bore the T\u2010follicular helper phenotype (PD1, ICOS, and BCL6) and were positive for CD25 and chemokine receptor 4. <jats:italic>Epstein\u2010Barr virus encoded RNA<\/jats:italic>\u2010positive cells were scattered in the background via in situ hybridization. The histological findings were similar to those of AITL\/nTFHL\u2010AI; however, the immunohistochemical results did not exclude the possibility of ATLL. Southern blot analysis detected integration of HTLV\u20101 proviral DNA. The <jats:italic>RHOA Gly 17 Val (G17V)<\/jats:italic> mutation was detected by the peptide nucleic acid\u2010locked nucleic acid clamp method. Finally, the patient was diagnosed with ATLL with AITL\u2010like feature and exhibited a similar morphology, immunophenotype, and mutational signature to AITL\/nTFHL\u2010AI. ATLL mimics other types of T\u2010cell lymphomas. Thus, in HTLV\u20101 endemic areas, routine screening for HTLV\u20101 serology is necessary to avoid misdiagnosis of other lymphoid malignancies.<\/jats:p>","DOI":"10.1111\/pin.13477","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T11:14:08Z","timestamp":1725016448000},"page":"641-647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adult T\u2010cell leukemia\/lymphoma with angioimmunoblastic T\u2010cell lymphoma\u2010like feature and molecularly confirmed <i>RHOA Gly 17 Val (G17V)<\/i> mutation: A case report"],"prefix":"10.1111","volume":"74","author":[{"given":"Rika","family":"Maruyama","sequence":"first","affiliation":[{"name":"Department of Hematology Oita City Medical Association's Almeida Memorial Hospital Oita 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