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Immunohistochemical analysis was performed on 91 tubo\u2010ovarian carcinoma samples to determine the presence of GATA3\u2010positive inflammatory cells in the tumor microenvironment. A threshold of 10% or higher was considered a positive expression. The results showed that 46.7% of tubo\u2010ovarian carcinomas exhibited positive expression of GATA3 in inflammatory cells. There was no significant difference in GATA3 expression between patients who received pre\u2010surgical chemotherapy and those who underwent primary surgery. However, high\u2010grade serous carcinomas had a significantly higher proportion of GATA3\u2010positive inflammatory cells compared to other subtypes. Advanced\u2010stage tumors (stage III) had a higher percentage of GATA3\u2010positive inflammatory cells compared to stage II and I tumors. Patients with positive GATA3 expression had a significantly lower disease\u2010free survival rate. However, there was no significant association between GATA3 expression and chemotherapy response score. These findings suggest that increased expression of GATA3 in mononuclear inflammatory cells is associated with higher grade, advanced stage, and increased risk of recurrence in tubo\u2010ovarian carcinoma. This implies that heightened GATA3 expression negatively impacts anti\u2010tumor immunity, tumor growth progression, and invasiveness in tubo\u2010ovarian carcinomas.<\/jats:p>","DOI":"10.1111\/pin.13488","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T10:45:05Z","timestamp":1730889905000},"page":"682-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["GATA3 expression in tumor\u2010infiltrating mononuclear inflammatory cells is associated with poor prognostic factors in tubo\u2010ovarian carcinomas"],"prefix":"10.1111","volume":"74","author":[{"given":"Fatemeh","family":"Nili","sequence":"first","affiliation":[{"name":"Department of Pathology, Imam Khomeini Hospital Complex, School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5408-3911","authenticated-orcid":false,"given":"Elham","family":"Mirzaian","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr Shariati Hospital, School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahereh","family":"Doustmohammadi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Imam Khomeini Hospital Complex, School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somayeh","family":"Moradpanah","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Dr Shariati Hospital, School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fereshteh","family":"Ameli","sequence":"additional","affiliation":[{"name":"Department of Pathology, Imam Khomeini Hospital Complex, School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soheila","family":"Sarmadi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yas Hospital Complex, School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niusha","family":"Momeni","sequence":"additional","affiliation":[{"name":"Department of Pathology, Imam Khomeini Hospital Complex, School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S197604"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/cco-20-34"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2016.0084"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14092230"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2016.08.006"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cf3d79"},{"key":"e_1_2_14_8_1","unstructured":"CheungAN EllensonLH GilksCB et al. editors. 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