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Pathologic findings of the primary pancreatic tumor were heterogeneous, but they essentially categorized into two components based on their cytologic features: (i) clear cell component and (ii) epithelioid cell component. The metastatic hepatic tumor was entirely composed of the epithelioid cell component. SMARCB1 expression was lost by immunohistochemistry and heterozygous deletion of <jats:italic>SMARCB1<\/jats:italic> was identified by fluorescence in situ hybridization for both the primary and metastatic tumors. Targeted DNA sequencing of a metastatic hepatic tumor sample was performed and <jats:italic>SMARCB1<\/jats:italic> loss was identified. Based on the morphologic, immunohistochemical, and molecular analyzes, the present case was difficult to classify into any of the existing entities. SMARCB1 deficiency might play a key role in the tumorigenesis.<\/jats:p>","DOI":"10.1111\/pin.13489","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T13:53:53Z","timestamp":1730123633000},"page":"691-696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SMARCB1\u2010deficient malignant neoplasm of the pancreas with heterogeneous morphologies that cannot be classified into existing histologic types"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3434-1263","authenticated-orcid":false,"given":"Yusuke","family":"Kouchi","sequence":"first","affiliation":[{"name":"Department of Molecular Pathology, Graduate School of Medicine Chiba University Chuo\u2010ku Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomu","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Graduate 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