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We report a 56\u2010year\u2010old woman with FDCS arising in the parapharyngeal space in the background of HV\u2010UCD. The patient presented with a painless right neck mass and extensive cervical lymphadenopathy without systemic symptoms. Surgical resection of the parapharyngeal mass revealed FDCS in the lymph nodes with features of HV\u2010UCD. Immunohistochemistry confirmed the follicular dendritic cell lineage of the lesional cells, with positivity for CD21 and CD23. Subsequent lymph node dissection from levels 2A, 2B, 3, and 4 showed features of HV\u2010UCD without residual FDCS. This case highlights the diagnostic challenge FDCS represents, particularly when arising in an unusual location. While complete surgical excision remains the standard of care, long\u2010term follow\u2010up is necessary to monitor for recurrence or metastasis.<\/jats:p>","DOI":"10.1111\/pin.70007","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T05:26:20Z","timestamp":1743744380000},"page":"236-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Follicular Dendritic Cell Sarcoma of the Parapharyngeal Space Arising in Association With Castleman Disease"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8868-9700","authenticated-orcid":false,"given":"Shunsuke","family":"Koga","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9460-7473","authenticated-orcid":false,"given":"Wei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel C.","family":"Caponetti","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumarasen","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"562","article-title":"A Primary Lymph Node Malignancy With Features Suggestive of Dendritic Reticulum Cell Differentiation. 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