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Histological features were characterized by nuclear atypia, diffuse growth, sinusoidal invasion, and mucin deposition in most stromal regions, leading to the diagnosis of a myxoid adrenocortical carcinoma (ACC). Whole exome sequencing analysis revealed 1p deletion and other several mutations without <jats:italic>TP53<\/jats:italic> nor <jats:italic>CTNNB1<\/jats:italic> mutations. Following surgery and adjuvant mitotane therapy, the patient showed no recurrence at a 5\u2010year follow\u2010up. Myxoid ACC is an exceedingly rare tumor characterized by mucus deposits in tumor stroma with high malignant potential. Despite the identification of crucial driver gene mutations such as <jats:italic>TP53<\/jats:italic> and <jats:italic>CTNNB1<\/jats:italic> in ACC, the genetic background of the myxoid ACC remains unclear. This case was the first case report of myxoid ACC with a 1p deletion, which was reported to be detected in 67% of ACC and 9% of adenoma but not in hyperplasia, supporting the correlation of this aberration with tumorigenesis. In conclusion, 1p deletion may be relevant to tumorigenesis in myxoid ACC.<\/jats:p>","DOI":"10.1111\/pin.70045","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T11:36:51Z","timestamp":1755603411000},"page":"471-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Myxoid Adrenocortical Carcinoma With 1p Deletion Identified by Whole Exome Sequencing"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5619-6925","authenticated-orcid":false,"given":"Naomi","family":"Sato","sequence":"first","affiliation":[{"name":"Division of Pathological Diagnosis Tohoku Medical and Pharmaceutical University Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Pathology National Hospital Organization Sendai Medical Center Sendai Miyagi 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