{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:19:28Z","timestamp":1772986768015,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Recent reports have revealed various morphological features of\n                    <jats:italic>ALK<\/jats:italic>\n                    \u2010rearranged mesenchymal neoplasms but their characteristics remain to be elucidated. Here, we report a case of\n                    <jats:italic>ALK<\/jats:italic>\n                    \u2010rearranged mesenchymal neoplasm with novel morphological features. A 32\u2010year\u2010old man had an intra\u2010abdominal mass measuring 75\u2009mm in diameter. Histologically, the tumor consisted of many lymphoid follicles with wide fibrosis or hyalinization. The follicles were characterized by regressed germinal centers and expanded mantle zones. Hyalinized blood vessels were distributed in the follicular and interfollicular areas. These histological findings resembled those of hyaline\u2010vascular type unicentric Castleman disease (HV\u2010UCD). However, the fibrous areas exhibited histological findings similar to inflammatory myofibroblastic tumor (IMT), which is characterized by the proliferation of spindle or stellate\u2010shaped fibroblastic cells accompanied by lymphoid, eosinophil, and plasma cell infiltration. Immunohistochemically, ALK\u2010positive spindle cells were observed in the follicular, interfollicular, and fibrous areas. Molecular analysis revealed fusion between\n                    <jats:italic>ATIC<\/jats:italic>\n                    (exon 7) and\n                    <jats:italic>ALK<\/jats:italic>\n                    (exon 20). Immunofluorescence staining suggested that ALK\u2010positive tumor cells in follicular areas were derived from CD23\u2010positive follicular dendritic cells, and those in interfollicular areas were derived from \u03b1\u2010SMA\u2010positive fibroblastic reticular cells or myofibroblasts. Therefore, we report an extremely rare case of\n                    <jats:italic>ALK<\/jats:italic>\n                    \u2010rearranged mesenchymal neoplasm with features of both HV\u2010UCD and IMT.\n                  <\/jats:p>","DOI":"10.1111\/pin.70052","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T11:30:54Z","timestamp":1758886254000},"page":"538-543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>ALK\u2010<\/i>\n                    Rearranged Mesenchymal Neoplasm With Hyaline\u2010Vascular Castleman Disease\u2010Like Features: A Case Report"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4647-1639","authenticated-orcid":false,"given":"Haruna","family":"Yagi","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Aichi Japan"},{"name":"Department of Pathology and Molecular Diagnostics Aichi Cancer Center Hospital Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Satou","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Department of Regenerative and Infectious Pathology Hamamatsu University School of Medicine Hamamatsu Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayu","family":"Fujihiro","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Hamamatsu University School of Medicine Hospital Hamamatsu Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5516-4737","authenticated-orcid":false,"given":"Yuichi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pathology Fukuoka Pathology Clinic Fukuoka Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery Nagoya University Graduate School of Medicine Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Hamamatsu University School of Medicine Hospital Hamamatsu Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihide","family":"Iwashita","sequence":"additional","affiliation":[{"name":"Department of Regenerative and Infectious Pathology Hamamatsu University School of Medicine Hamamatsu Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennosuke","family":"Karube","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"WHO Classification of Tumours Editorial Board edn","author":"WHO Classification of Soft Tissue and Bone Tumours","year":"2020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.49"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semdp.2025.150947"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002283"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.23097"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15239"},{"key":"e_1_2_10_8_1","volume-title":"WHO Classification of Tumours Editorial Board edn","author":"WHO Classification of Haematolymphoid tumours","year":"2024"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10040251"},{"key":"e_1_2_10_10_1","first-page":"513","volume-title":"Practical Soft Tissue Pathology: A Diagnostic Approach","author":"Hornick J. 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