{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T21:22:10Z","timestamp":1767043330020,"version":"3.48.0"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Although rare, thyroid follicular nodular disease (TFND) may exhibit a nodule\u2010in\u2010nodule (NN) appearance with solid\/trabecular (ST) components (STc). While the STc has histologically aggressive features compared to the outer nodule (Out\u2010N) in TFND, its pathological significance remains unclear. We present a case of TFND with STc in a 63\u2010year\u2010old man who developed skin implantation and lung metastases 3 years after lobectomy. Histologically, the skin tumor resembled STc with high mitotic activity. Molecular analysis revealed\n                    <jats:italic>EZH1<\/jats:italic>\n                    mutations in both the Out\u2010N and STc of TFND, while\n                    <jats:italic>KRAS<\/jats:italic>\n                    and\n                    <jats:italic>TERT<\/jats:italic>\n                    promoter mutations were restricted to STc and the skin tumor. These findings suggest that the STc of NN may be a precursor to poorly differentiated thyroid carcinoma arising from well\u2010differentiated components through stepwise mutations. This case highlights the malignant potential of certain Noninvasive TFNDs and suggests the need for further analyses to clarify this hypothesis and reconsider their classification and management.\n                  <\/jats:p>","DOI":"10.1111\/pin.70058","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:23:31Z","timestamp":1760556211000},"page":"624-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Malignant Potential of Thyroid Follicular Nodular Disease With Solid\/Trabecular Components: A Case Report"],"prefix":"10.1111","volume":"75","author":[{"given":"Mayu","family":"Ueda","sequence":"first","affiliation":[{"name":"Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute Nagasaki University Nagasaki Nagasaki Japan"},{"name":"Thyroid Cancer Collaborative Research Center, Atomic Bomb Disease Institute Nagasaki University Nagasaki Nagasaki Japan"},{"name":"Department of Endocrinology and Metabolism Nagasaki University Graduate School of Biomedical Sciences Nagasaki Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7345-2014","authenticated-orcid":false,"given":"Katsuya","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute Nagasaki University Nagasaki Nagasaki Japan"},{"name":"Thyroid Cancer Collaborative Research Center, Atomic Bomb Disease Institute Nagasaki University Nagasaki Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Mori","sequence":"additional","affiliation":[{"name":"Yamashita Thyroid Hospital Fukuoka Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Kurohama","sequence":"additional","affiliation":[{"name":"Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute Nagasaki University Nagasaki Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5050-2509","authenticated-orcid":false,"given":"Hiroyuki","family":"Mishima","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Atomic Bomb Disease Institute Nagasaki University Nagasaki Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koh\u2010Ichiro","family":"Yoshiura","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Atomic Bomb Disease Institute Nagasaki University Nagasaki Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norisato","family":"Mitsutake","sequence":"additional","affiliation":[{"name":"Thyroid Cancer Collaborative Research Center, Atomic Bomb Disease Institute Nagasaki University Nagasaki Nagasaki Japan"},{"name":"Department of Molecular Oncology, Atomic Bomb Disease Institute Nagasaki University Nagasaki Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisakazu","family":"Shindo","sequence":"additional","affiliation":[{"name":"Yamashita Thyroid Hospital Fukuoka Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Sato","sequence":"additional","affiliation":[{"name":"Yamashita Thyroid Hospital Fukuoka Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0805-8886","authenticated-orcid":false,"given":"Hiroyuki","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Yamashita Thyroid Hospital Fukuoka Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Nagasaki University Graduate School of Biomedical Sciences Nagasaki Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9036-8735","authenticated-orcid":false,"given":"Masahiro","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute Nagasaki University Nagasaki Nagasaki Japan"},{"name":"Thyroid Cancer Collaborative Research Center, Atomic Bomb Disease Institute Nagasaki University Nagasaki Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"volume-title":"Endocrine and Neuroendocrine Tumours","year":"2022","author":"WHO Classification of Tumours Editorial Board","key":"e_1_2_11_2_1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-022-09707-3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14153577"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.08.011"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-015-9410-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","DOI":"10.1177\/01455613241239533","article-title":"Thyroid Cancer With Cutaneous Metastases","volume":"14","author":"Sciscent B. Y.","year":"2024","journal-title":"Ear, Nose, & Throat Journal"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-019-05161-1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896914531814"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.04.018"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84894"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-019-09586-1"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20413"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-15-0533"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ23-0136"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0509"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28800"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.70058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T21:17:24Z","timestamp":1767043044000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.70058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/pin.70058"],"URL":"https:\/\/doi.org\/10.1111\/pin.70058","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"type":"print","value":"1320-5463"},{"type":"electronic","value":"1440-1827"}],"subject":[],"published":{"date-parts":[[2025,10,15]]},"assertion":[{"value":"2025-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}