{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:57:12Z","timestamp":1775858232919,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We recently identified a high prevalence of the MCD\u2010like subtype in primary sinonasal DLBCL, defined by\n                    <jats:italic>MYD88<\/jats:italic>\n                    L265P and\/or\n                    <jats:italic>CD79B<\/jats:italic>\n                    Y196 mutations, which is associated with poor prognosis and preferred relapse sites. In this study, we characterized 56 primary pharyngeal DLBCLs and compared them with 55 sinonasal cases from our prior cohort, assessing mutations by droplet digital PCR and immunophenotype by immunohistochemistry. Pharyngeal and sinonasal DLBCLs exhibited site\u2010specific heterogeneity, with pharyngeal cases showing lower frequencies of\n                    <jats:italic>MYD88<\/jats:italic>\n                    L265P (15\/56 [26.8%] vs. 29\/55 [52.7%],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007) and\n                    <jats:italic>CD79B<\/jats:italic>\n                    Y196 mutations (15\/56 [26.8%] vs. 20\/55 [36.4%],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.312), and correspondingly fewer MCD\u2010like cases (20\/56 [35.7%] vs. 32\/55 [58.2%],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.023). Nevertheless, MCD\u2010like pharyngeal cases shared similar features with sinonasal MCD\u2010like cases, including high tendencies for non\u2010GCB phenotype (75% vs. 96.9%), inferior prognosis, and specific site relapse (CNS, testis, and\/or skin). Across the entire upper airway cohort (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009111), MCD\u2010like status consistently correlated with site\u2010specific relapse and adverse clinical outcomes. These findings support expanding the utility of simplified MCD\u2010like classification as a practical tool for prognostic prediction, relapse site estimation, and therapeutic guidance in upper airway DLBCL, with potential for broader application to anatomically diverse DLBCL\u2010NOS cases.\n                  <\/jats:p>","DOI":"10.1111\/pin.70071","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T12:30:52Z","timestamp":1766061052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>MYD88<\/i>\n                    and\n                    <i>CD79B<\/i>\n                    Mutation Analysis in Primary Pharyngeal Diffuse Large B\u2010Cell Lymphomas: Expanding the MCD\u2010Like Subtype From the Sinonasal Region to the Upper Airway"],"prefix":"10.1111","volume":"76","author":[{"given":"Fangli","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Pathology and Oncology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuro","family":"Igawa","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oncology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Respiratory Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Isoda","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama Medical Center Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawako","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oncology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetaka","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oncology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"463","volume-title":"World Health Organization Classification of Tumours of Haematolymphoid Tumours","author":"Rosenwald A. 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