{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T17:32:32Z","timestamp":1769707952753,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Asthma is a recognized risk factor for nontuberculous mycobacterial (NTM) pulmonary infections, yet the precise routes of infection and dissemination remain visually unclear. We analyzed a rare surgical case of asthma complicated by\n                    <jats:italic>Mycobacterium avium<\/jats:italic>\n                    \u2013associated lung cavity formation in a young adult. Following antibiotic treatment, the patient underwent left upper segmentectomy, with successful subsequent treatment of residual lesions using amikacin liposome inhalation suspension. To precisely visualize the infection route, we utilized a three\u2010dimensional merged whole block imaging (WBI) technique. Fifteen formalin\u2010fixed paraffin\u2010embedded tissue blocks from the resected lung were individually scanned using a custom\u2010built micro\u2010computed tomography system, reconstructed, and combined to generate merged\u2010WBI. Three core merged\u2010WBIs revealed that the remodeled asthma\u2010associated airway ascended from the proximal hilar region, intertwined with surrounding epithelioid granulomatous tissue, and then descended into a subpleural cavity composed of epithelioid granulomas with central caseous necrosis containing acid\u2010fast bacilli. Besides the distinct airway path, the WBI delineated the distribution of minor epithelioid granulomas and calcifications. This report provides the first three\u2010dimensional visualization of a continuous airway route extending from the hilum to a subpleural cavity using merged\u2010WBI, suggesting bronchial spread as a probable mechanism of NTM dissemination in the setting of chronic airway disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Clinical trial registration:<\/jats:bold>\n                    No clinical trials.\n                  <\/jats:p>","DOI":"10.1111\/pin.70074","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:52:36Z","timestamp":1767171156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Micro\u2010Computed Tomography Based Whole Block Imaging of Asthma\u2010Associated Airway Remodeling With\n                    <i>Mycobacterium avium<\/i>\n                    \u2010Induced Cavity Formation: 3\u2010Dimensional Nondestructive Analysis"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7502-8724","authenticated-orcid":false,"given":"Tetsuya","family":"Tsukamoto","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Lab Medicine Memorial Sloan Kettering Cancer Center New York City New York USA"},{"name":"Division of Analytical Pathology, Oncology Innovation Center Fujita Health University Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Hoshikawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexei","family":"Teplov","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Lab Medicine Memorial Sloan Kettering Cancer Center New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiko","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Pathology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisato","family":"Ishizawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmy","family":"Yanagita","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Lab Medicine Memorial Sloan Kettering Cancer Center New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Ushida","sequence":"additional","affiliation":[{"name":"Department of Pathology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Asai","sequence":"additional","affiliation":[{"name":"Department of Pathology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukako","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Lab Medicine Memorial Sloan Kettering Cancer Center New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(02)00022-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0186"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.02076.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442387"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/2153-3539.170647"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01619-2023"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0094"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0400"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.13353599"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.07738"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0605-1"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12040984"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14161704"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1546-8063"},{"key":"e_1_2_11_16_1","first-page":"339","volume-title":"Robbins & Cotran Pathologic Basis of Disease","author":"Frank K. M.","year":"2021"},{"key":"e_1_2_11_17_1","volume-title":"Pathology Illustrated","author":"Roberts F.","year":"2019"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2022.01.012"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008632"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.70074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pin.70074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.70074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T05:56:17Z","timestamp":1769666177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.70074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,31]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/pin.70074"],"URL":"https:\/\/doi.org\/10.1111\/pin.70074","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,31]]},"assertion":[{"value":"2025-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70074"}}