{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:43Z","timestamp":1787015983014,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Amphicrine carcinoma is a rare malignancy exhibiting dual differentiation toward both exocrine and endocrine lineages within the same tumor cells. We report a case of pancreatic amphicrine carcinoma with acinar and neuroendocrine differentiation in an elderly man (85 years old at surgery). An 8\u2010mm nodule in the pancreatic body was detected by abdominal ultrasonography. Magnetic resonance imaging revealed a high\u2010signal nodule on diffusion\u2010weighted imaging but indistinct findings on T1\u2010 and T2\u2010weighted images, and the lesion was also indistinct on dynamic contrast\u2010enhanced computed tomography. Endoscopic ultrasonography (EUS) clearly visualized the lesion, and EUS\u2010guided fine\u2010needle aspiration revealed malignant cells with acinar\u2010like structures and granular cytoplasm. Distal pancreatectomy was subsequently performed, and the tumor was pathologically diagnosed as amphicrine carcinoma. Dual differentiation toward acinar and neuroendocrine lineages was confirmed by immunohistochemistry and ultrastructural examination. To our knowledge, this is the first report to comprehensively describe a pancreatic acinar\u2010type amphicrine carcinoma, including radiological, cytopathological, and ultrastructural findings. The present case highlights the diagnostic value of multimodal imaging and cytopathological evaluation and may serve as a reference for diagnosing such rare tumors. It may also offer new insights into the future classification of pancreatic amphicrine and amphicrine\u2010like tumors within a similar biological spectrum.<\/jats:p>","DOI":"10.1111\/pin.70094","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T11:32:36Z","timestamp":1771241556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pancreatic Amphicrine Carcinoma With Acinar and Neuroendocrine Differentiation: A Comprehensive Case With Radiological, Cytopathological and Ultrastructural Findings, and Literature Review"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1455-4974","authenticated-orcid":false,"given":"Hirotsugu","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Pathology Tokyo Women's Medical University Tokyo Japan"},{"name":"Department of Diagnostic Pathology NTT Medical Center Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology NTT Medical Center Tokyo Tokyo Japan"},{"name":"Department of Molecular Pathology Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouichi","family":"Satou","sequence":"additional","affiliation":[{"name":"Department of Surgery NTT Medical Center Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Medicine NTT Medical Center Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Kusakabe","sequence":"additional","affiliation":[{"name":"Department of Radiology NTT Medical Center Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology NTT Medical Center Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"370","volume-title":"WHO Classification of Tumours. 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