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Antigen testing and real\u2010time PCR confirmed COVID\u201019 infection. Histopathologic examination revealed granulomatous inflammation consistent with GCA throughout the aorta. Moreover, the medial layer showed widespread amyloid deposits, some of which were phagocytosed by multinucleated GCs and macrophages. Proteomic analysis using laser microdissection and liquid chromatography\u2013tandem mass spectrometry confirmed that the deposits primarily comprise lactadherin, particularly medin peptides. Immunohistochemistry with antisera directed against three medin sequences confirmed immunoreactivity in the amyloid deposits (medin\u2010derived amyloid [AMed]), as well as in the cytoplasm of adjacent histiocytes and multinucleated GCs. In addition, postmortem serum analysis revealed markedly elevated interleukin\u20106 (IL\u20106) levels (383\u2009pg\/mL; reference \u2264\u20097.0\u2009pg\/mL). These findings suggest that the cause of death was multi\u2010organ failure resulting from a systemic inflammatory response associated with COVID\u201019. IL\u20106 is strongly implicated in GCA pathogenesis. By analogy with vasculitides associated with other age\u2010related amyloids, GCA is suggested to result from an immune response targeting AMed deposits. Taken together, GCA in this case may have developed via an immune response to AMed triggered by COVID\u201019\u2013related IL\u20106 elevation.<\/jats:p>","DOI":"10.1111\/pin.70100","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:24:05Z","timestamp":1772997845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Giant Cell Arteritis With Medin\u2010Derived Amyloid (AMed) Deposition in a Patient With COVID\u201019: An Autopsy Case"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7305-8137","authenticated-orcid":false,"given":"Shojiro","family":"Ichimata","sequence":"first","affiliation":[{"name":"Department of Legal Medicine, Faculty of Medicine University of Toyama Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuneaki","family":"Yoshinaga","sequence":"additional","affiliation":[{"name":"Department of 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