{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:08:07Z","timestamp":1774609687016,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008673","name":"Yasuda Memorial Medical Foundation","doi-asserted-by":"publisher","award":["501100008673"],"award-info":[{"award-number":["501100008673"]}],"id":[{"id":"10.13039\/501100008673","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tumor spread through air spaces (STAS) is a histological feature associated with poor prognosis in primary lung cancer, but its relevance in colorectal cancer (CRC) pulmonary metastases remains unclear. This study evaluated the prognostic impact of STAS in CRC pulmonary metastases and its association with histologic features of the primary tumor. A total of 124 patients who underwent pulmonary resection for CRC metastases were retrospectively analyzed. Quantitative STAS parameters, including density and maximum spread distance, were assessed histologically. Survival outcomes were analyzed using Kaplan\u2013Meier and Cox proportional hazards models, and logistic regression identified predictors of STAS. STAS was present in 33.1% of patients and was associated with significantly shorter 5\u2010year recurrence\u2010free survival (18.7% vs. 53.0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) and overall survival (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Quantitative STAS metrics correlated with intrathoracic recurrence. Patients with high tumor budding grade had a significantly higher STAS\u2010positive rate than those with none or low grade (60% vs. 31.2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.036). Tumor budding independently predicted STAS (odds ratio: 3.19, 95% confidence interval: 1.05\u20139.69,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.040). STAS independently predicted poor prognosis, particularly intrathoracic recurrence. Quantitative STAS assessment enhanced prognostic precision, and tumor budding grade may serve as a preoperative marker for predicting STAS.\n                  <\/jats:p>","DOI":"10.1111\/pin.70107","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T04:32:30Z","timestamp":1774499550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spread Through Air Spaces in Colorectal Lung Metastases Signals Local Recurrenece and Reflects Morphologic Aggressiveness of the Primary Tumor"],"prefix":"10.1111","volume":"76","author":[{"given":"Taketo","family":"Nakai","sequence":"first","affiliation":[{"name":"Department of Surgery Keio University School of Medicine Tokyo 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