{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:04:15Z","timestamp":1777950255290,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We report a multicystic intrahepatic neoplasm in a 54\u2010year\u2010old Japanese woman, representing a previously unrecognized subtype. Grossly, the lesion was a well\u2010demarcated multicystic tumor with focal papillary projections. Histologically, the cysts were lined by columnar to cuboidal neoplastic cells with brush border\u2010like luminal microvilli, abundant granular eosinophilic cytoplasm, and small round nuclei. The cystic lumina contained colloid\u2010like secretion, and bile\u2010filled glands were occasionally observed. The septa were composed of thin hepatocellular parenchyma. Immunohistochemically, the tumor cells were positive for CD10, CK7, CK19, EpCAM, and SPINK1 and negative for HepPar1, MUC1, MUC2, MUC5AC, and MUC6. Whole\u2010exome sequencing identified a pathogenic somatic\n                    <jats:italic>KRAS<\/jats:italic>\n                    p.G12V variant. RNA sequencing detected no\n                    <jats:italic>PRKACA\/B<\/jats:italic>\n                    fusions. Single\u2010cell spatial transcriptomics demonstrated that tumor cells clustered most closely with septal and medium\u2010sized interlobular bile ducts. Gene set activity analysis showed significant suppression of gene sets downregulated by KRAS activation and upregulation of KRAS dependency signature gene sets in tumor cells. These findings distinguish this lesion from established entities of intrahepatic biliary cystic neoplasms, including intraductal papillary neoplasm, intraductal tubulopapillary neoplasm, intraductal oncocytic papillary neoplasm, and mucinous cystic neoplasm. We propose the designation \u201ceosinophilic biliary cystic neoplasm of the liver\u201d for this distinct intrahepatic biliary neoplasm.\n                  <\/jats:p>","DOI":"10.1111\/pin.70114","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T05:53:27Z","timestamp":1776405207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eosinophilic Biliary Cystic Neoplasm of the Liver: A Case Report of an Unrecognized Subtype of Intrahepatic Biliary Neoplasm"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6877-9212","authenticated-orcid":false,"given":"Mariko","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Pathology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daizo","family":"Koinuma","sequence":"additional","affiliation":[{"name":"Department of Pathology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munetoshi","family":"Hinata","sequence":"additional","affiliation":[{"name":"Department of Pathology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimiko","family":"Takeshita","sequence":"additional","affiliation":[{"name":"Department of Pathology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4809-7561","authenticated-orcid":false,"given":"Yoichi","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Pathology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Department of Pathology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Takamoto","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiro","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8734-740X","authenticated-orcid":false,"given":"Kiyoshi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudai","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1763-8380","authenticated-orcid":false,"given":"Tetsuo","family":"Ushiku","sequence":"additional","affiliation":[{"name":"Department of Pathology, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"279","volume-title":"Intraductal Papillary Neoplasm of the Bile Ducts. 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