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This study examined Cell Adhesion Molecule 1 (CADM1) and the differentially expressed in adenocarcinoma of the lung\u20101 expression in 75 resected GEP\u2010NETs and evaluated their associations with clinicopathological features, tumor grade, and established adhesion\u2010 or prognosis\u2010related markers, including E\u2010cadherin (ECAD), CD56, progesterone receptor (PgR), and cytokeratin 19 (CK19). CADM1 promoter methylation was assessed using methylation\u2010specific PCR, and the miR\u2010214 and miR\u2010375 expressions were analyzed by quantitative real\u2010time PCR. The expression of CADM1 was significantly lower in tumors with lymph node and\/or distant metastasis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01), and a low CADM1 expression was independently associated with metastatic disease (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0004; OR\u2009=\u20094.63). Additionally, low PgR (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014; OR\u2009=\u20094.13) and a high CK19 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0002; OR\u2009=\u20094.83) expression, as reported previously, were linked to poor outcomes. In contrast, neither ECAD nor CD56 showed any notable associations with aggressive features in a univariable assessment. No significant relationship was observed between CADM1 promoter methylation and the CADM1 expression. These findings suggest that a reduced CADM1 expression may be associated with lymph node and distant metastasis in GEP\u2010NETs and could be a potential prognostic marker.\n                  <\/jats:p>","DOI":"10.1111\/pin.70122","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:59:25Z","timestamp":1781117965000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low Expression of Cell Adhesion Molecule 1 in Resected Gastroenteropancreatic Neuroendocrine Tumors: Relationship With Lymph Node and Distant Metastasis"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0105-7027","authenticated-orcid":false,"given":"Ken","family":"Miyabe","sequence":"first","affiliation":[{"name":"Department of Quantitative Pathology Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7013-0503","authenticated-orcid":false,"given":"Michinobu","family":"Umakoshi","sequence":"additional","affiliation":[{"name":"Department of Quantitative Pathology Akita University Graduate School of Medicine  Akita Japan"},{"name":"Department of Pathology Akita City Hospital Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukitsugu","family":"Kudo\u2010Asabe","sequence":"additional","affiliation":[{"name":"Department of Quantitative Pathology Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Quantitative Pathology Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Ishinari","sequence":"additional","affiliation":[{"name":"Department of Quantitative Pathology Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayana","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Quantitative Pathology Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Tsukita","sequence":"additional","affiliation":[{"name":"Department of Quantitative Pathology Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1774-1169","authenticated-orcid":false,"given":"Yukinobu","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Pathology, Graduate School of Medical Sciences Kanazawa University Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Course of Occupational Therapy, Department of Health Sciences Akita Uversity Graduate School of Health Sciences Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Akita Kosei Medical Center Akita Japan"},{"name":"Tsubakidai Pathology Clinic Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Pathology Akita Kosei Medical Center Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Sageshima","sequence":"additional","affiliation":[{"name":"Department of Pathology Akita City Hospital Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nanjo","sequence":"additional","affiliation":[{"name":"Division of Clinical Pathology Akita University Hospital Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-4396","authenticated-orcid":false,"given":"Yoshinori","family":"Murakami","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology, The Institute of Medical Science The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8776-9004","authenticated-orcid":false,"given":"Akiteru","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Quantitative Pathology Akita University Graduate School of Medicine  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4377"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.03.304"},{"key":"e_1_2_12_4_1","volume-title":"Digestive System Tumours; 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