{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:02:39Z","timestamp":1779962559931,"version":"3.53.1"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    (\n                    <jats:italic>Hp<\/jats:italic>\n                    )\u2013na\u00efve gastric mucosa has been characterized histologically by the absence of\n                    <jats:italic>Hp<\/jats:italic>\n                    organisms, atrophy, and intestinal metaplasia (IM). We conducted a prospective multicenter study to clarify the prevalence and clinicopathologic features of IM in the\n                    <jats:italic>Hp<\/jats:italic>\n                    \u2010na\u00efve stomach.\n                    <jats:italic>Hp<\/jats:italic>\n                    \u2010na\u00efve individuals with regional gastric mucosal abnormalities detected by endoscopy were enrolled. Biopsies were obtained from target lesions and adjacent mucosa. IM frequency and Updated Sydney System (USS) scores were assessed by glandular background (pyloric vs. fundic) in both target and adjacent samples. Among 52 target and 56 adjacent samples, pyloric and fundic gland mucosa accounted for 28 and 24 target samples and 21 and 35 adjacent samples, respectively. IM was detected exclusively in pyloric gland mucosa of target lesions (46.4% vs. 0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and was absent in adjacent mucosa. Atrophy scores were low overall but significantly higher in pyloric than fundic gland mucosa in both target lesions (median [IQR], 1 [1\u20132] vs. 0 [0\u20131],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and adjacent mucosa (1 [1\u20132] vs. 1 [0\u20131],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). All IM lesions were classified as incomplete type, showing predominant small intestinal\u2010type differentiation with residual gastric foveolar markers. Histological evaluation of\n                    <jats:italic>Hp<\/jats:italic>\n                    \u2010na\u00efve gastric mucosa should be region\u2010specific, with attention to glandular architecture.\n                  <\/jats:p>","DOI":"10.1111\/pin.70126","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:31:26Z","timestamp":1779082286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incomplete Intestinal Metaplasia in Pyloric Gland Mucosa of\n                    <i>Helicobacter pylori<\/i>\n                    \u2010Na\u00efve Stomachs: A Prospective Multicenter Histopathologic Study"],"prefix":"10.1111","volume":"76","author":[{"given":"Shinsuke","family":"Suemitsu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine Shimane University  Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3583-2707","authenticated-orcid":false,"given":"Kotaro","family":"Shibagaki","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Shimane University Hospital  Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Pathology Shimane University Hospital  Izumo Japan"},{"name":"Department of Pathology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Miyaoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shimane Prefectural Central Hospital  Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology National Hospital Organization Hamada Medical Center  Hamada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Mishiro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Unnan City Hospital  Unnan Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Aimi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tottori Municipal Hospital  Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine Shimane University  Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kotani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine Shimane University  Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Fukuba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine Shimane University  Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8039-3155","authenticated-orcid":false,"given":"Norihisa","family":"Ishimura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine Shimane University  Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamiko","family":"Nagase","sequence":"additional","affiliation":[{"name":"Department of Pathology Shimane University Hospital  Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Department of Pathology Shimane University Hospital  Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Niino","sequence":"additional","affiliation":[{"name":"Department of Pathology Shimane University Hospital  Izumo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Kushima","sequence":"additional","affiliation":[{"name":"Department of Pathology Shiga University of Medical Science  Otsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunji","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine Shimane University  Izumo 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